Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/57980

TitleAsymmetrical subcortical plasticity entails cognitive progression in older individuals
Author(s)Esteves, Madalena
Moreira, Pedro S.
Marques, Paulo
Castanho, Teresa Jesus Costa
Magalhães, Ricardo
Amorim, Liliana Patrícia Carvalho
Nunes, José Carlos Leitão Portugal
Soares, José M.
Coelho, Ana
Almeida, Armando
Santos, Nadine Correia
Sousa, Nuno
Leite-Almeida, Hugo
KeywordsAging
Cognition
MRI
Structural laterality
MMSE
Stroop
Issue date2019
PublisherWiley
JournalAging Cell
CitationEsteves, M., Moreira, P. S., Marques, P., Castanho, T. C., Magalhães, R., Amorim, L., ... & Santos, N. C. (2019). Asymmetrical subcortical plasticity entails cognitive progression in older individuals. Aging Cell, e12857
Abstract(s)Structural brain asymmetries have been associated with cognition. However, it is not known to what extent neuropsychological parameters and structural laterality covary with aging. Seventy-five subjects drawn from a larger normal aging cohort were evaluated in terms of MRI and neuropsychological parameters at two moments (M1 and M2), 18 months apart. In this time frame, asymmetry as measured by structural laterality index (ΔLI) was stable regarding both direction and magnitude in all areas. However, a significantly higher dispersion for this variation was observed in subcortical over cortical areas. Subjects with extreme increase in rightward lateralization of the caudate revealed increased M1 to M2 Stroop interference scores, but also a worsening of general cognition (MMSE). In contrast, subjects showing extreme increase in leftward lateralization of the thalamus presented higher increase in Stroop interference scores. In conclusion, while a decline in cognitive function was observed in the entire sample, regional brain asymmetries were relatively stable. Neuropsychological trajectories were associated with laterality changes in subcortical regions.
TypeArticle
DescriptionFor peer review
URIhttp://hdl.handle.net/1822/57980
DOI10.1111/acel.12857
ISSN1474-9718
e-ISSN1474-9726
Publisher versionhttps://onlinelibrary.wiley.com/doi/full/10.1111/acel.12857
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee


Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID