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TitleMultilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions
Author(s)Yoris, Adrián
Abrevaya, Sofía
Esteves, Sol
Salamone, Paula
Lori, Nicolas Francisco
Martorell, Miguel
Legaz, Agustina
Alifano, Florencia
Petroni, Agustín
Sánchez, Ramiro
Sedeño, Lucas
García, Adolfo M.
Ibáñez, Agustín
Diffusion Tensor Imaging
Evoked Potentials
Gray Matter
Magnetic Resonance Imaging
Multilevel Analysis
Neural Pathways
Organ Size
heart evoked potential
embodied cognition
Issue date2018
JournalHuman Brain Mapping
CitationYoris, A., Abrevaya, S., Esteves, S., Salamone, P., Lori, N., Martorell, M., ... & Sedeño, L. (2018). Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body–brain interactions. Human brain mapping, 39(4), 1563-1581
Abstract(s)Interoception, the sensing of visceral body signals, involves an interplay between neural and autonomic mechanisms. Clinical studies into this domain have focused on patients with neurological and psychiatric disorders, showing that damage to relevant brain mechanisms can variously alter interoceptive functions. However, the association between peripheral cardiac-system alterations and neurocognitive markers of interoception remains poorly understood. To bridge this gap, we examined multidimensional neural markers of interoception in patients with early stage of hypertensive disease (HTD) and healthy controls. Strategically, we recruited only HTD patients without cognitive impairment (as shown by neuropsychological tests), brain atrophy (as assessed with voxel-based morphometry), or white matter abnormalities (as evidenced by diffusion tensor imaging analysis). Interoceptive domains were assessed through (a) a behavioral heartbeat detection task; (b) measures of the heart-evoked potential (HEP), an electrophysiological cortical signature of attention to cardiac signals; and (c) neuroimaging recordings (MRI and fMRI) to evaluate anatomical and functional connectivity properties of key interoceptive regions (namely, the insula and the anterior cingulate cortex). Relative to controls, patients exhibited poorer interoceptive performance and reduced HEP modulations, alongside an abnormal association between interoceptive performance and both the volume and functional connectivity of the above regions. Such results suggest that peripheral cardiac-system impairments can be associated with abnormal behavioral and neurocognitive signatures of interoception. More generally, our findings indicate that interoceptive processes entail bidirectional influences between the cardiovascular and the central nervous systems.
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Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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