Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/57951

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dc.contributor.authorTaipa, Ricardo Jorge Ferreirapor
dc.contributor.authorFerreira, V.por
dc.contributor.authorBrochado, P.por
dc.contributor.authorRobinson, Apor
dc.contributor.authorReis, I.por
dc.contributor.authorMarques, Fernandapor
dc.contributor.authorMann, D. M.por
dc.contributor.authorMelo-Pires, M.por
dc.contributor.authorSousa, Nunopor
dc.date.accessioned2019-01-09T11:09:29Z-
dc.date.issued2018-
dc.identifier.citationTaipa, R., Ferreira, V., Brochado, P., Robinson, A., Reis, I., Marques, F., ... & Sousa, N. (2018). Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study. Neuropathology and applied neurobiology, 44(3), 298-313por
dc.identifier.issn0305-1846-
dc.identifier.urihttp://hdl.handle.net/1822/57951-
dc.description.abstractThe association between the pathological features of AD and dementia is stronger in younger old persons than in older old persons suggesting that additional factors are involved in the clinical expression of dementia in the oldest old. Cumulative data suggests that neuroinflammation plays a prominent role in Alzheimer's disease (AD) and different studies reported an age-associated dysregulation of the neuroimmune system. Consequently, we sought to characterize the pattern of microglial cell activation and astrogliosis in brain post mortem tissue of pathologically confirmed cases of early and late onset AD (EOAD and LOAD) and determine their relation to age.por
dc.description.sponsorship‘Bolsa para Investigação’ of Centro Hospitalar do Porto. The work at ICVS/3B's has been developed under the scope of the project NORTE‐01‐0145‐FEDER‐000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER), and funded by FEDER funds through the Competitiveness Factors Operational Programme (COMPETE), and the Foundation for Science and Technology (FCT), under the scope of the project POCI‐01‐0145‐FEDER‐007038. We acknowledge The Manchester Brain Bank, The Queen Square Brain Bank and the Oxford Brain Bank [supported by the Medical Research Council (MRC), the NIHR Oxford Biomedical Research Centre and the Brains for Dementia Research programme, jointly funded by Alzheimer′s Research UK and Alzheimer′s Society] for tissue samples supplypor
dc.language.isoengpor
dc.publisherWileypor
dc.rightsembargoedAccess (1 Year)por
dc.subjectAgeingpor
dc.subjectAlzheimer´s diseasepor
dc.subjectAstrocytespor
dc.subjectMicrogliapor
dc.subjectPathologypor
dc.titleInflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem studypor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1111/nan.12445por
dc.commentsauthor can archive post-print (ie final draft post-refereeing)por
degois.publication.firstPage298por
degois.publication.lastPage313por
degois.publication.issue3por
degois.publication.volume44por
dc.identifier.essn1365-2990-
dc.identifier.doi10.1111/nan.12445por
dc.date.embargo2020-01-01-
dc.identifier.pmc29044639por
dc.subject.fosCiências Médicas::Medicina Básicapor
dc.description.publicationversioninfo:eu-repo/semantics/publishedVersionpor
dc.subject.wosScience & Technologypor
sdum.journalNeuropathology and Applied Neurobiologypor
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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