Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/57951

TítuloInflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study
Autor(es)Taipa, Ricardo Jorge Ferreira
Ferreira, V.
Brochado, P.
Robinson, A
Reis, I.
Marques, Fernanda
Mann, D. M.
Melo-Pires, M.
Sousa, Nuno
Palavras-chaveAgeing
Alzheimer´s disease
Astrocytes
Microglia
Pathology
Data2018
EditoraWiley
RevistaNeuropathology and Applied Neurobiology
CitaçãoTaipa, R., Ferreira, V., Brochado, P., Robinson, A., Reis, I., Marques, F., ... & Sousa, N. (2018). Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study. Neuropathology and applied neurobiology, 44(3), 298-313
Resumo(s)The association between the pathological features of AD and dementia is stronger in younger old persons than in older old persons suggesting that additional factors are involved in the clinical expression of dementia in the oldest old. Cumulative data suggests that neuroinflammation plays a prominent role in Alzheimer's disease (AD) and different studies reported an age-associated dysregulation of the neuroimmune system. Consequently, we sought to characterize the pattern of microglial cell activation and astrogliosis in brain post mortem tissue of pathologically confirmed cases of early and late onset AD (EOAD and LOAD) and determine their relation to age.
Tipoarticle
URIhttp://hdl.handle.net/1822/57951
DOI10.1111/nan.12445
ISSN0305-1846
e-ISSN1365-2990
Versão da editorahttps://onlinelibrary.wiley.com/doi/full/10.1111/nan.12445
Arbitragem científicayes
AcessoembargoedAccess (1 Year)
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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