Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/57948

TitleTrait determinants of impulsive behavior: a comprehensive analysis of 188 rats
Author(s)Soares, Ana Rosa
Esteves, Madalena
Moreira, Pedro Miguel Silva
Cunha, Ana Margarida Ferreira
Guimarães, Marco Rafael Machado
Carvalho, Miguel Murteira
Raposo-Lima, Catarina
Morgado, Pedro
Carvalho, Ana Raquel Franky Gomes
Coimbra, Bárbara Guimarães Salazar
Melo, António
Rodrigues, Ana João
Salgado, A. J.
Pêgo, José M.
Cerqueira, João José
Costa, Patrício Soares
Sousa, Nuno
Almeida, Armando
Leite-Almeida, Hugo
Issue date5-Dec-2018
PublisherNature Research
JournalScientific Reports
CitationSoares, A. R., Esteves, M., Moreira, P. S., Cunha, A. M., Guimarães, M. R., Carvalho, M. M., ... & Melo, A. (2018). Trait determinants of impulsive behavior: a comprehensive analysis of 188 rats. Scientific reports, 8(1), 17666
Abstract(s)Impulsivity is a naturally occurring behavior that, when accentuated, can be found in a variety of neuropsychiatric disorders. The expression of trait impulsivity has been shown to change with a variety of factors, such as age and sex, but the existing literature does not reflect widespread consensus regarding the influence of modulating effects. We designed the present study to investigate, in a cohort of significant size (188 rats), the impact of four specific parameters, namely sex, age, strain and phase of estrous cycle, using the variable delay-to-signal (VDS) task. This cohort included (i) control animals from previous experiments; (ii) animals specifically raised for this study; and (iii) animals previously used for breeding purposes. Aging was associated with a general decrease in action impulsivity and an increase in delay tolerance. Females generally performed more impulsive actions than males but no differences were observed regarding delay intolerance. In terms of estrous cycle, no differences in impulsive behavior were observed and regarding strain, Wistar Han animals were, in general, more impulsive than Sprague-Dawley. In addition to further confirming, in a substantial study cohort, the decrease in impulsivity with age, we have demonstrated that both the strain and sex influences modulate different aspects of impulsive behavior manifestations.
TypeArticle
URIhttp://hdl.handle.net/1822/57948
DOI10.1038/s41598-018-35537-7
ISSN2045-2322
e-ISSN2045-2322
Publisher versionhttps://www.nature.com/articles/s41598-018-35537-7
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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