Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/57937

TitleThe Role of Biomaterials as Angiogenic Modulators of Spinal Cord Injury: Mimetics of the Spinal Cord, Cell and Angiogenic Factor Delivery Agents
Author(s)Rocha, Luís A.
Sousa, Rui A.
Learmonth, David A.
Salgado, A. J.
KeywordsSpinal cord injury
Angiogenesis
Vascularization
Biomaterials
Growth factors
Issue date2018
PublisherFrontiers Media
JournalFrontiers in Pharmacology
CitationRocha, L. A., Sousa, R. A., Learmonth, D., & Salgado, A. J. (2018). The Role of Biomaterials as Angiogenic Modulators of Spinal Cord Injury: Mimetics of the Spinal Cord, Cell and Angiogenic Factor Delivery Agents. Frontiers in pharmacology, 9, 164
Abstract(s)Spinal cord injury (SCI) represents an extremely debilitating condition for which no efficacious treatment is available. One of the main contributors to the inhospitable environment found in SCI is the vascular disruption that happens at the moment of injury that compromises the blood-spinal cord barrier (BSCB) and triggers a cascade of events that includes infiltration of inflammatory cells, ischemia and intraparenchymal hemorrhage. Due to the unsatisfactory nature of revascularization following SCI, restoring vascular perfusion and the BSCB seems an interesting way of modulating the lesion environment into a regenerative phenotype, with a potential increase in functional recovery. Certain biomaterials possess interesting features to enhance SCI therapies, and in fact have been applied as angiogenic promoters in other pathologies. The present mini-review intends to highlight the contribution that biomaterials could make in the development of novel therapeutic solutions able to restore proper vascularization and the BSCB.
TypeArticle
URIhttp://hdl.handle.net/1822/57937
DOI10.3389/fphar.2018.00164
ISSN1663-9812
Publisher versionhttps://www.frontiersin.org/articles/10.3389/fphar.2018.00164/full
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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