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dc.contributor.authorKafetzopoulos, V.por
dc.contributor.authorKokras, N.por
dc.contributor.authorSotiropoulos, I.por
dc.contributor.authorOliveira, João F.por
dc.contributor.authorLeite-Almeida, Hugopor
dc.contributor.authorVasalou, A.por
dc.contributor.authorSardinha, Vanessa Alexandra Moraispor
dc.contributor.authorPapadopoulou-Daifoti, Zpor
dc.contributor.authorAlmeida, O. F. X.por
dc.contributor.authorAntoniou, K.por
dc.contributor.authorSousa, Nunopor
dc.contributor.authorDalla, C.por
dc.identifier.citationKafetzopoulos, V., Kokras, N., Sotiropoulos, I., Oliveira, J. F., Leite-Almeida, H., Vasalou, A., ... & Sousa, N. (2018). The nucleus reuniens: a key node in the neurocircuitry of stress and depression. Molecular psychiatry, 23(3), 579por
dc.descriptionUncorrected proofpor
dc.description.abstractThe hippocampus and prefrontal cortex (PFC) are connected in a reciprocal manner: whereas the hippocampus projects directly to the PFC, a polysynaptic pathway that passes through the nucleus reuniens (RE) of the thalamus relays inputs from the PFC to the hippocampus. The present study demonstrates that lesioning and/or inactivation of the RE reduces coherence in the PFC-hippocampal pathway, provokes an antidepressant-like behavioral response in the forced swim test and prevents, but does not ameliorate, anhedonia in the chronic mild stress (CMS) model of depression. Additionally, RE lesioning before CMS abrogates the well-known neuromorphological and endocrine correlates of CMS. In summary, this work highlights the importance of the reciprocal connectivity between the hippocampus and PFC in the establishment of stress-induced brain pathology and suggests a role for the RE in promoting resilience to depressive illness.por
dc.description.sponsorshipGreece for providing sertraline. This work was supported by an ‘Education and Lifelong Learning, Supporting Postdoctoral Researchers’, co-financed by the European Social Fund (ESF) and the General Secretariat for Research and Technology, Greece, the Life and Health Sciences Research Institute (ICVS), ON.2—O NOVO NORTE—North Portugal Regional Operational Program 2007/2013 of the National Strategic Reference Framework (NSRF) 2007/2013 through the European Regional Development Fund (ERDF), the Portuguese Foundation for Science and Technology (FCT; grant no. NMC-113934) and an InEurope program funded by International Brain Research Organizationpor
dc.publisherSpringer Naturepor
dc.titleThe nucleus reuniens: a key node in the neurocircuitry of stress and depressionpor
dc.commentsauthor can archive post-print (ie final draft post-refereeing)por
dc.subject.fosCiências Médicas::Medicina Básicapor
dc.subject.wosScience & Technologypor
sdum.journalMolecular Psychiatrypor
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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