Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/5786
Título: | Human papillomavirus testing as an optional screening tool in low-resource settings of Latin America: experience from the Latin American Screening study |
Autor(es): | Longatto Filho, Adhemar Eržen, M. Branca, M. Roteli-Martins, C. Naud, P. Derchain, S. F. Hammes, L. Sarian, L. O. Bragança, J. F. Matos, J. C. Gontijo, R. Lima, T. P. Maeda, Marina Yoshiê Sakamoto Tatti, S. Syrjänen, K. Dôres, Gerson B. das Lörincz, A. Syrjänen, K. |
Palavras-chave: | Cervical cancer HPV testing Low-resource setting Screening low resource setting |
Data: | 2006 |
Editora: | Lippincott, Williams & Wilkins |
Revista: | International journal of gynecological cancer |
Citação: | "International journal of gynecological cancer". ISSN 1048-891X. 16:3 (May/June 2006) 995-962. |
Resumo(s): | Hybrid capture II (HC II) test for oncogenic human papillomaviruses (HPV) was carried out in a cohort of 4284 women at their first clinical visit. Overall prevalence of HPV was 17.1%, decreasing with age from 33.9% among women below 20 years to only 11.0% among those older than 41 years. HPV prevalence was significantly higher among current smokers (odds ratio [OR] ¼ 1.31; 95% CI 1.1–1.6), in women with two or more lifetime sexual partners (OR ¼ 1.9; 95% CI 1.6–2.4), and those women with two or more sexual partners during the past 12 months prior to examination (OR ¼ 1.6; 95% CI 1.2–2.2). HPV detection increased in parallel with increasing cytologic abnormality, being highest in women with high-grade squamous intraepithelial lesion (P ¼ 0.001). Specificity of the HPV test in detecting histologically confirmed cervical disease was 85% (95% CI 83.9–86.1). Sensitivity of the HPV test in detecting histologic abnormalities increased in parallel with disease severity, ranging from 51.5% for cervical intraepithelial neoplasia (CIN) 1 to 96.5% for CIN 3 and 100.0% for cancer, with respective decline of positive predictive value. These data suggest that HPV testing with HC II assay might be a viable screening tool among this population with relatively high prevalence of cervical disease. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/5786 |
DOI: | 10.1111/j.1525-1438.2006.00582.x |
ISSN: | 1048-891X |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
HC2 optional screening tool Incodev.pdf | 169,34 kB | Adobe PDF | Ver/Abrir |