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TitleHuman papillomavirus testing as an optional screening tool in low-resource settings of Latin America: experience from the Latin American Screening study
Author(s)Longatto Filho, Adhemar
Eržen, M.
Branca, M.
Roteli-Martins, C.
Naud, P.
Derchain, S. F.
Hammes, L.
Sarian, L. O.
Bragança, J. F.
Matos, J. C.
Gontijo, R.
Lima, T. P.
Maeda, Marina Yoshiê Sakamoto
Tatti, S.
Syrjänen, K.
Dôres, Gerson B. das
Lörincz, A.
Syrjänen, K.
KeywordsCervical cancer
HPV testing
Low-resource setting
resource setting
Issue date2006
PublisherLippincott, Williams & Wilkins
JournalInternational journal of gynecological cancer
Citation"International journal of gynecological cancer". ISSN 1048-891X. 16:3 (May/June 2006) 995-962.
Abstract(s)Hybrid capture II (HC II) test for oncogenic human papillomaviruses (HPV) was carried out in a cohort of 4284 women at their first clinical visit. Overall prevalence of HPV was 17.1%, decreasing with age from 33.9% among women below 20 years to only 11.0% among those older than 41 years. HPV prevalence was significantly higher among current smokers (odds ratio [OR] ¼ 1.31; 95% CI 1.1–1.6), in women with two or more lifetime sexual partners (OR ¼ 1.9; 95% CI 1.6–2.4), and those women with two or more sexual partners during the past 12 months prior to examination (OR ¼ 1.6; 95% CI 1.2–2.2). HPV detection increased in parallel with increasing cytologic abnormality, being highest in women with high-grade squamous intraepithelial lesion (P ¼ 0.001). Specificity of the HPV test in detecting histologically confirmed cervical disease was 85% (95% CI 83.9–86.1). Sensitivity of the HPV test in detecting histologic abnormalities increased in parallel with disease severity, ranging from 51.5% for cervical intraepithelial neoplasia (CIN) 1 to 96.5% for CIN 3 and 100.0% for cancer, with respective decline of positive predictive value. These data suggest that HPV testing with HC II assay might be a viable screening tool among this population with relatively high prevalence of cervical disease.
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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