Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/57846

TitleFunctional Hemispheric (A)symmetries in the Aged Brain-Relevance for Working Memory
Author(s)Esteves, Madalena
Magalhães, Ricardo José Silva
Marques, Paulo
Castanho, Teresa Jesus Costa
Portugal-Nunes, Carlos
Soares, José M.
Almeida, Armando
Santos, Nadine Correia
Sousa, Nuno
Leite-Almeida, Hugo
Keywordslaterality
N-back
aging
fMRI
superior parietal
Issue date2018
PublisherFrontiers Media
JournalFrontiers in Aging Neuroscience
CitationEsteves, M., Magalhães, R., Marques, P., Castanho, T. C., Portugal-Nunes, C., Soares, J. M., ... & Leite-Almeida, H. (2018). Functional Hemispheric (A) symmetries in the Aged Brain—Relevance for Working Memory. Frontiers in aging neuroscience, 10, 58
Abstract(s)Functional hemispheric asymmetries have been described in different cognitive processes, such as decision-making and motivation. Variations in the pattern of left/right activity have been associated with normal brain functioning, and with neuropsychiatric diseases. Such asymmetries in brain activity evolve throughout life and are thought to decrease with aging, but clear associations with cognitive function have never been established. Herein, we assessed functional laterality during a working memory task (N-Back) in a healthy aging cohort (over 50 years old) and associated these asymmetries with performance in the test. Activity of lobule VI of the cerebellar hemisphere and angular gyrus was found to be lateralized to the right hemisphere, while the precentral gyrus presented left > right activation during this task. Interestingly, 1-Back accuracy was positively correlated with left > right superior parietal lobule activation, which was mostly due to the influence of the left hemisphere. In conclusion, although regions were mostly symmetrically activated during the N-Back task, performance in working memory in aged individuals seems to benefit from lateralized involvement of the superior parietal lobule.
TypeArticle
URIhttp://hdl.handle.net/1822/57846
DOI10.3389/fnagi.2018.00058
ISSN1663-4365
Publisher versionhttps://www.frontiersin.org/articles/10.3389/fnagi.2018.00058/full
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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