Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/57829

TítuloMetabolism and adult neurogenesis: Towards an understanding of the role of lipocalin-2 and iron-related oxidative stress
Autor(es)Ferreira, Ana Catarina
Sousa, Nuno
Peixoto, João Miguel Seiça Bessa
Sousa, João Carlos
Marques, Fernanda
Palavras-chaveNeurogenesis
Metabolism
Oxidative stress
Lipocalin-2
DataDez-2018
EditoraPergamon-Elsevier Science Ltd
RevistaNeuroscience and Biobehavioral Reviews
CitaçãoFerreira, A. C., Sousa, N., Bessa, J. M., Sousa, J. C., & Marques, F. (2018). Metabolism and adult neurogenesis: towards an understanding of the role of lipocalin-2 and iron-related oxidative stress. Neuroscience & Biobehavioral Reviews
Resumo(s)The process of generating new functional neurons in the adult mammalian brain occurs from the local neural stem and progenitor cells and requires tight control of the progenitor cell's activity. Several signaling pathways and intrinsic/extrinsic factors have been well studied over the last years, but recent attention has been given to the critical role of cellular metabolism in determining the functional properties of progenitor cells. Here, we review recent advances in the current understanding of when and how metabolism affects neural stem cell (NSC) behavior and subsequent neuronal differentiation and highlight the role of lipocalin-2 (LCN2), a protein involved in the control of oxidative stress, as a recently emerged regulator of NSC activity and neuronal differentiation.
Tipoarticle
DescriçãoAccepted manuscript
URIhttp://hdl.handle.net/1822/57829
DOI10.1016/j.neubiorev.2018.09.014
ISSN0149-7634
e-ISSN1873-7528
Versão da editorahttps://www.sciencedirect.com/science/article/pii/S014976341830280X
Arbitragem científicayes
AcessoembargoedAccess (3 Years)
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee


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