Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/57820

TítuloRegion-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats
Autor(es)Duarte, Joana Mendes
Gaspar, Rita
Caetano, Liliana
Patrício, Patrícia
Cunha, Carina Isabel Soares
Pinheiro, António Maria Restolho Mateus
Alves, Nuno Dinis Lopes Oliveira
Santos, Ana Rita
Ferreira, Samira G.
Sardinha, Vanessa Alexandra Morais
Oliveira, João F.
Fontes-Ribeiro, Carlos
Sousa, Nuno
Cunha, Rodrigo A.
Ambrósio, António F.
Pinto, Luísa
Rodrigues, Ana João
Gomes, Catarina A.
Palavras-chaveA(2A) receptors
anxiety
cognition
gender dimorphism
microglia morphology
A receptors 2A
DataJan-2019
EditoraWiley
RevistaGlia
CitaçãoDuarte, J. M., Gaspar, R., Caetano, L., Patrício, P., Soares‐Cunha, C., Mateus‐Pinheiro, A., ... & Oliveira, J. F. (2018). Region‐specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats. Glia
Resumo(s)Epidemiologic studies have provided compelling evidence that prenatal stress, through excessive maternal glucocorticoids exposure, is associated with psychiatric disorders later in life. We have recently reported that anxiety associated with prenatal exposure to dexamethasone (DEX, a synthetic glucocorticoid) correlates with a gender-specific remodeling of microglia in the medial prefrontal cortex (mPFC), a core brain region in anxiety-related disorders. Gender differences in microglia morphology, the higher prevalence of anxiety in women and the negative impact of anxiety in cognition, led us to specifically evaluate cognitive behavior and associated circuits (namely mPFC-dorsal hippocampus, dHIP), as well as microglia morphology in female rats prenatally exposed to dexamethasone (in utero DEX, iuDEX). We report that iuDEX impaired recognition memory and deteriorated neuronal synchronization between mPFC and dHIP. These functional deficits are paralleled by microglia hyper-ramification in the dHIP and decreased ramification in the mPFC, showing a heterogeneous remodeling of microglia morphology, both postnatally and at adulthood in different brain regions, that differently affect mood and cognition. The chronic blockade of adenosine A2A receptors (A2A R), which are core regulators of microglia morphology and physiology, ameliorated the cognitive deficits, but not the anxiety-like behavior. Notably, A2A R blockade rectified both microglia morphology in the dHIP and the lack of mPFC-dHIP synchronization, further heralding their role in cognitive function.
Tipoarticle
URIhttp://hdl.handle.net/1822/57820
DOI10.1002/glia.23476
ISSN0894-1491
e-ISSN1098-1136
Versão da editorahttps://onlinelibrary.wiley.com/doi/full/10.1002/glia.23476
Arbitragem científicayes
AcessoembargoedAccess (1 Year)
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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