Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/57808

TítuloImmune Thymic Profile of the MOG-Induced Experimental Autoimmune Encephalomyelitis Mouse Model
Autor(es)Neves, Sofia Pereira
Miranda, Cláudia Sofia Serre
Nobrega, Claudia
Roque, Susana
Cerqueira, João José
Correia-Neves, M
Marques, Fernanda
Multiple sclerosis
Experimental autoimmune encephalomyelitis
EditoraFrontiers Media
RevistaFrontiers in Immunology
Citaçãodas Neves, S. P., Serre-Miranda, C., Nobrega, C., Roque, S., Cerqueira, J. J., Correia-Neves, M., & Marques, F. (2018). Immune thymic profile of the MOG-induced experimental autoimmune encephalomyelitis mouse model. Frontiers in immunology, 9, 2335
Resumo(s)Multiple sclerosis (MS) is a chronic, immune-mediated, demyelinating disease that affects the neurons of the central nervous system. Activated T cells, specific for myelin epitopes, cross the brain barriers, and react against the myelin sheath, leading to demyelination. Since T cells are generated within the thymus, here we explored, in mice, the alterations occurring in this organ throughout the different phases of the disease. We induced experimental autoimmune encephalomyelitis (EAE) in C57BL/6 females and sacrifice them at the onset (day 16) and chronic phases of disease (day 23), along with non-induced controls. We observed thymic atrophy in EAE mice at the onset that remained until the chronic phase of disease. This atrophy was associated with a preferential loss of the CD4+CD8+ double positive thymocytes, an intermediate population between the more immature CD4-CD8- double negative and the most mature single positive thymocytes. This was accompanied by an increase in the thymic medullary/cortical ratio and by an altered expression levels of genes important for T cell survival. During the chronic phase, the thymi remained atrophic, but reacquired the normal proportion of the main four thymocyte populations and the normal medullary/cortical ratio. Importantly, at the onset phase, and accompanying these thymic alterations, EAE animals presented an increased percentage of demyelinating lesion area in the cerebellum, and an increased expression of interferon gamma (Ifng), interleukin (Il) 12a, and Il17a. This study suggests dynamic thymic alterations occurring in response to EAE, from the induction to the chronic phase, that might help to elucidate the MS pathophysiology.
Versão da editorahttps://www.frontiersin.org/articles/10.3389/fimmu.2018.02335/full
Arbitragem científicayes
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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