Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/57714

TitleDevelopment of multifunctional liposomes containing magnetic/plasmonic MnFe2O4/Au core/shell nanoparticles
Author(s)Rodrigues, Ana Rita Oliveira
Matos, Joana O. G.
Dias, Armando M. Nova
Almeida, B. G.
Pires, Ana
Pereira, André M.
Araújo, João P.
Queiroz, Maria João R. P.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
KeywordsMagnetic/plasmonic nanoparticles
Multifunctional liposomes
Manganese ferrite
Gold shell
Antitumor drugs
Cancer therapy
Issue date2019
PublisherMDPI Publishing
JournalPharmaceutics
CitationRodrigues, A.R.O.; Matos, J.O.G.; Nova Dias, A.M.; Almeida, B.G.; Pires, A.; Pereira, A.M.; Araújo, J.P.; Queiroz, M.-J.R.P.; Castanheira, E.M.S.; Coutinho, P.J.G. Development of Multifunctional Liposomes Containing Magnetic/Plasmonic MnFe2O4/Au Core/Shell Nanoparticles. Pharmaceutics 2019, 11, 10.
Abstract(s)Multifunctional liposomes containing manganese ferrite/gold core/shell nanoparticles were developed. These magnetic/plasmonic nanoparticles were covered by a lipid bilayer or entrapped in liposomes, which form solid or aqueous magnetoliposomes as nanocarriers for simultaneous chemotherapy and phototherapy. The core/shell nanoparticles were characterized by UV/Visible absorption, X-Ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and Superconducting Quantum Interference Device (SQUID). The magnetoliposomes were characterized by Dynamic Light Scattering (DLS) and TEM. Fluorescence-based techniques (FRET, steady-state emission, and anisotropy) investigated the incorporation of a potential anti-tumor drug (a thienopyridine derivative) in these nanosystems. The core/shell nanoparticles exhibit sizes of 25 ± 2 nm (from TEM), a plasmonic absorption band (λmax = 550 nm), and keep magnetic character. XRD measurements allowed for the estimation of 13.3 nm diameter for manganese ferrite core and 11.7 nm due to the gold shell. Aqueous magnetoliposomes, with hydrodynamic diameters of 152 ± 18 nm, interact with model membranes by fusion and are able to transport the anti-tumor compound in the lipid membrane, with a high encapsulation efficiency (EE (%) = 98.4 ± 0.8). Solid magnetoliposomes exhibit hydrodynamic diameters around 140 nm and also carry successfully the anticancer drug (with EE (%) = 91.2 ± 5.2), while also being promising as agents for phototherapy. The developed multifunctional liposomes can be promising as therapeutic agents for combined chemo/phototherapy.
TypeArticle
URIhttp://hdl.handle.net/1822/57714
DOI10.3390/pharmaceutics11010010
e-ISSN1999-4923
Publisher versionhttps://www.mdpi.com/1999-4923/11/1/10
Peer-Reviewedyes
AccessOpen access
Appears in Collections:PHYSICS OF QUANTUM MATERIALS AND BIONANOSTRUCTURES (2018 - ...)

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