Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/57362

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dc.contributor.authorDíaz, E.por
dc.contributor.authorValle, M. B.por
dc.contributor.authorRibeiro, S.por
dc.contributor.authorLanceros-Méndez, S.por
dc.contributor.authorBarandiarán, J. M.por
dc.date.accessioned2018-12-17T22:39:08Z-
dc.date.available2018-12-17T22:39:08Z-
dc.date.issued2018-
dc.identifier.citationDíaz, E.; Valle, M.B.; Ribeiro, S.; Lanceros-Mendez, S.; Barandiarán, J.M. Development of Magnetically Active Scaffolds for Bone Regeneration. Nanomaterials 2018, 8, 678.por
dc.identifier.issn2079-4991por
dc.identifier.urihttp://hdl.handle.net/1822/57362-
dc.description.abstractThis work reports on the synthesis, with the thermally induced phase separation (TIPS) technique, of poly (L-lactide) (PLLA) scaffolds containing Fe-doped hydroxyapatite (FeHA) particles for bone regeneration. Magnetization curves and X-ray diffraction indicate two magnetic particle phases: FeHA and magnetite Fe3O4. Magnetic nanoparticles (MNPs) are approximately 30 ± 5 nm in width and 125 ± 25 nm in length, and show typical ferromagnetic properties, including coercivity and rapid saturation magnetization. Scanning electron microscopy (SEM) images of the magnetic scaffolds reveal their complex morphology changes with MNP concentration. Similarly, at compositions of approximately 20% MNPs, the phase separation changes, passing from solid–liquid to liquid–liquid as revealed by the hill-like structures, with low peaks that give the walls in the SEM images a surface pattern of micro-ruggedness typical of nucleation mechanisms and growth. In vitro degradation experiments, carried out for more than 28 weeks, demonstrated that the MNPs delay the scaffold degradation process. Cytotoxicity is appreciated for FeHA content above 20%.por
dc.description.sponsorshipThis work was supported by the University of The Basque Center and the Portuguese Foundation for Science and Technology (FCT) under the framework Strategic Funding UID/FIS/04650/ UID/BIA/04050/2013, and UID/BIO/04469. S.R. would like to the FCT for the SFRH/BD/111478/2015 grant. The authors acknowledge funding by the Spanish Ministry of Economy and Competitiveness (MINECO) under the project MAT2016-76039-C4-3-R (AEI/FEDER, UE)por
dc.language.isoengpor
dc.publisherMDPI AGpor
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147414/PTpor
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147364/PTpor
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147337/PTpor
dc.relationSFRH/BD/111478/2015por
dc.rightsopenAccesspor
dc.subjectCytotoxicitypor
dc.subjectFe-doped hydroxyapatitepor
dc.subjectMagnetismpor
dc.subjectPoly (L-lactide)por
dc.subjectScaffoldspor
dc.titleDevelopment of magnetically active scaffolds for bone regenerationpor
dc.typearticlepor
dc.peerreviewedyespor
oaire.citationIssue9por
oaire.citationVolume8por
dc.identifier.doi10.3390/nano8090678por
dc.description.publicationversioninfo:eu-repo/semantics/publishedVersionpor
dc.subject.wosScience & Technologypor
sdum.journalNanomaterialspor
Appears in Collections:CDF - FCD - Artigos/Papers (with refereeing)
DBio - Artigos/Papers

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