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https://hdl.handle.net/1822/57196
Título: | Clotrimazole multiple W/O/W emulsion as anticandidal agent: Characterization and evaluation on skin and mucosae |
Autor(es): | Soriano-Ruiz, José L. Suñer-Carbó, Joaquim Calpena-Campmany, Ana C. Febrer, Nuria Bozal-de Halbaut-Bellowa, Lyda Boix-Montañés, Antonio Souto, Eliana B. Clares-Naveros, Beatriz |
Palavras-chave: | Clotrimazole multiple emulsion permeation skin mucosa |
Data: | 2019 |
Editora: | Elsevier |
Revista: | Colloids and Surfaces B: Biointerfaces |
Citação: | Soriano-Ruiz, José L.; Suñer-Carbó, Joaquim; Calpena-Campmany, Ana C.; Febrer, Nuria Bozal-de; Halbaut-Bellowa, Lyda; Boix-Montañés, Antonio; Souto, Eliana; Clares-Naveros, Beatriz, Clotrimazole multiple W/O/W emulsion as anticandidal agent: Characterization and evaluation on skin and mucosae. Colloids and Surfaces B: Biointerfaces, 175, 166-174, 2019 |
Resumo(s): | Clotrimazole (CLT) was formulated in a multiple W/O/W emulsion (ME) with the aim of evaluating its potential as topical anticandidal agent and comparing with marketed products. A previously evaluated CLT-ME was selected and physicochemically characterized. The in vitro release behavior and the ex vivo permeation profiles were assessed using Franz diffusion cells using three different types of biological membranes: human skin and porcine buccal, sublingual and vaginal mucosae. The antifungal activity against Candida strains was also tested. Results showed CLT-MEs sizes of 29.206 and 47.678??m with skin compatible pH values of 6.47 and 6.42 exhibiting high zeta potential values of -55.13 and -55.59?mV with dependence on the pH variation. The physicochemical stability was kept for a period of 180 days of storage at room temperature. CLT-MEs exhibited pseudoplastic behavior with hysteresis areas and viscosities of 286 and 331 mPa?s showing higher spreadability properties than commercial counterparts. An improved CLT release pattern was supplied by the ME system following a hyperbolic model. Likewise, ME system gave higher skin permeation flux of CLT than commercial reference. CLT amounts retained in the skin and mucosae were also higher than commercial references, which coupled with the higher antimycotic efficacy make CLT-MEs a great tool for clinical investigation of topical candidiasis treatments. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/57196 |
DOI: | 10.1016/j.colsurfb.2018.11.070 |
ISSN: | 0927-7765 |
Versão da editora: | http://www.journals.elsevier.com/colloids-and-surfaces-b-biointerfaces/ |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
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document_49338_1.pdf Acesso restrito! | 875,03 kB | Adobe PDF | Ver/Abrir |