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Title4-(4,5-Diphenyl-1H-imidazole-2-yl)-N,N-dimethylaniline-Cu(II) complex, a highly selective probe for glutathione sensing in water-acetonitrile mixtures
Author(s)Hazem, E. O.
Sayed, S. E.
Ferreira, R. C. M.
Costa, Susana P. G.
Raposo, M. Manuela M.
Martínez-Máñez, R.
Sancenón, F.
Chromo-fluorogenic detection
Cu(II) complex
Displacement assay
optical chemosensor
Issue date2018
JournalDyes and Pigments
CitationHazem, E. O.; Sayed, S. E.; Ferreira, R. C. M.; Costa, S. P. G.; Raposo, M. M. M., Martínez-Máñez, R.; Sancenón, F. 4-(4,5-Diphenyl-1H-imidazole-2-yl)-N,N-dimethylaniline-Cu(II) complex, a highly selective probe for glutathione sensing in water-acetonitrile mixtures. Dyes Pigments 2018, 159, 45-48.
Abstract(s)The imidazole derivative 4-(4,5-diphenyl-1H-imidazol-2-yl)-N,N-dimethylaniline (probe 1) formed a highly coloured and non-emissive 1:1 stoichiometry complex with Cu(II) in water-acetonitrile 1:1 (v/v) solutions. Among all the amino acids (Lys, Val, Gln, Leu, His, Thr, Trp, Gly, Phe, Arg, Ile, Met, Ser, Ala, Pro, Tyr, Gly, Asn, Asp, Glu, Cys and Hcy) and tripeptides (GSH) tested, only GSH induced the bleaching of the 1·Cu(II) solution together with a marked emission enhancement at 411 nm (excitation at 320 nm). These chromo-fluorogenic changes were ascribed to a selective GSH-induced demetallation of the 1·Cu(II) complex that resulted in a recovery of the spectroscopic features of probe 1. In addition to the remarkable selectivity of 1·Cu(II) complex toward GSH a competitive limit of detection as low as 2 μM was determined using fluorescence measurements.
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AccessOpen access
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