Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/57066

TitleChitosan/Copaiba oleoresin films for would dressing application
Author(s)Debone, H. S.
Lopes, Patrícia Santos
Severino, Patrícia
Yoshida, Cristiana Maria Pedroso
Souto, Eliana
Silva, Classius Ferreira da
KeywordsWound dressings
Copaiba oil
Copaifera L.
Chitosan
Films
Issue date30-Jan-2019
PublisherElsevier
JournalInternational Journal of Pharmaceutics
CitationDebone, H. S.; Lopes, Patrícia Santos; Severino, Patrícia; Yoshida, Cristiana Maria Pedroso; Souto, Eliana; Silva, Classius Ferreira da, Chitosan/Copaiba oleoresin films for would dressing application. International Journal of Pharmaceutics, 555, 146-152, 2019
Abstract(s)Biopolymeric films can be used as dressings for the treatment of skin burns and other chronic wounds. The healing properties of these films may be enhanced by the addition of Copaiba oil (Copaifera L.) which properties have already been well-described. The aim of this study was to evaluate the addition of Copaiba oil in chitosan films prepared by casting solvent evaporation technique using chitosan solution (2% or 1% wt/wt) and Copaiba oil (0.1 or 1.0% wt/wt) at different concentrations. Films were characterized by color analysis, scanning electron microscopy, mechanical properties, thermal analysis, and fluid handling capacity. The developed films demonstrated potential for wound dressing, translated by the fluid handling capacity similar to that of commercial dressings. While no surfactant was present in the formulation, the droplets of Copaiba oil were well-dispersed and homogeneously distributed in the chitosan matrix even after drying. The thermal analysis translated the occurrence of interactions between the oil and chitosan.
TypeArticle
DescriptionSupplementary data to this article can be found online at https://doi.org/10.1016/j.ijpharm.2018.11.054.
URIhttp://hdl.handle.net/1822/57066
DOI10.1016/j.ijpharm.2018.11.054
ISSN0378-5173
Publisher versionhttp://www.elsevier.com/locate/issn/03785173
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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