Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/56681

TítuloEngineering nanoparticles for targeting rheumatoid arthritis: Past, present, and future trends
Autor(es)Oliveira, Isabel Maria Lopes Matos
Gonçalves, C.
Reis, R. L.
Oliveira, J. M.
Palavras-chaveDendrimers
Liposomes
Nanoparticles
Rheumatoid arthritis
DataAbr-2018
EditoraTsinghua University Press
RevistaNano Research
CitaçãoOliveira I. M., Gonçalves C., Reis R. L., Oliveira J. M. Engineering nanoparticles for targeting rheumatoidarthritis: Past, present, and future trends, Nano Research, Vol. 11, Issue 9, pp. 1-18, doi:10.1007/s12274-018-2071-3, 2018
Resumo(s)Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial joint inflammation and cartilage and bone tissue destruction. Although there exist some treatment strategies for RA, they are not completely safe and effective. Therefore, it is important to develop and test new drugs for RA that specifically target inflamed/swollen joints and simultaneously attenuate other possible damages to healthy tissues. Nanotechnology can be a good alternative to consider when envisioning precise medication for treating RA. Through the use of nanoparticles, it is possible to increase bioavailability and bioactivity of therapeutics and enable selective targeting to damaged joints. Herein, recent studies using nanoparticles for the treatment of RA, namely with liposomes, polymeric nanoparticles, dendrimers, and metallic nanoparticles, have been reviewed. These therapeutic strategies have shown great promise in improving the treatment over that by traditional drugs. The results of these studies confirm that feasibility of the use of nanoparticles is mainly due to their biocompatibility, low toxicity, controlled release, and selective drug delivery to inflamed tissues in animal RA models. Therefore, it is possible to claim that nanotechnology will, in the near future, play a crucial role in advanced treatments and patient-specific therapies for human diseases such as RA.
Tipoarticle
URIhttp://hdl.handle.net/1822/56681
DOI10.1007/s12274-018-2071-3
ISSN1998-0124
Versão da editorahttps://link.springer.com/article/10.1007%2Fs12274-018-2071-3
Arbitragem científicano
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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