Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/56678

TítuloOrthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room
Autor(es)Cengiz, I. F.
Pereira, H.
de Girolamo, L.
Cucchiarini, M.
Espregueira-Mendes, João
Reis, R. L.
Oliveira, J. M.
Palavras-chaveBone
Cartilage
Clinical Translation
Ligament
Meniscus
Muscle
Scaffold
Stem cells
Tendon
DataDez-2018
EditoraSpringer
RevistaJournal of Experimental Orthopaedics
CitaçãoCengiz I. F., Pereira H., de Girolamo L., Cucchiarini M., Espregueira-Mendes J. D., Reis R. L., Oliveira J. M. Orthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room, Journal of Experimental Orthopaedics, Vol. 5, Issue 1, pp. 14, doi:10.1186/s40634-018-0133-9, 2018
Resumo(s)Orthopaedic disorders are very frequent, globally found and often partially unresolved despite the substantial advances in science and medicine. Their surgical intervention is multifarious and the most favourable treatment is chosen by the orthopaedic surgeon on a case-by-case basis depending on a number of factors related with the patient and the lesion. Numerous regenerative tissue engineering strategies have been developed and studied extensively in laboratory through in vitro experiments and preclinical in vivo trials with various established animal models, while a small proportion of them reached the operating room. However, based on the available literature, the current strategies have not yet achieved to fully solve the clinical problems. Thus, the gold standards, if existing, remain unchanged in the clinics, notwithstanding the known limitations and drawbacks. Herein, the involvement of regenerative tissue engineering in the clinical orthopaedics is reviewed. The current challenges are indicated and discussed in order to describe the current disequilibrium between the needs and solutions made available in the operating room. Regenerative tissue engineering is a very dynamic field that has a high growth rate and a great openness and ability to incorporate new technologies with passion to edge towards the Holy Grail that is functional tissue regeneration. Thus, the future of clinical solutions making use of regenerative tissue engineering principles for the management of orthopaedic disorders is firmly supported by the clinical need.
Tipoarticle
URIhttp://hdl.handle.net/1822/56678
DOI10.1186/s40634-018-0133-9
e-ISSN2197-1153
Versão da editorahttps://doi.org/10.1186/s40634-018-0133-9
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals


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