Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/56615

TitleMagnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the mode drug curcumin
Author(s)Cardoso, Beatriz D.
Rio, Irina S. R.
Rodrigues, Ana Rita Oliveira
Fernandes, Francisca C. T.
Almeida, B. G.
Pires, A.
Pereira, A. M.
Araújo, J. P.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
Keywordsmagnesium ferrite nanoparticles
magnetoliposomes
curcumin
superparamagnetism
pegylation
cancer therapy
Issue dateOct-2018
PublisherRoyal Society
JournalRoyal Society Open Science
CitationB. D. Cardoso, I. S. R. Rio, A. R. O. Rodrigues, F. C. T. Fernandes, B. G. Almeida, A. Pires, A. M. Pereira, J. P. Araújo, E. M. S. Castanheira, P. J. G. Coutinho, Royal Society Open Science, 5 (10) (2018) 181017
Abstract(s)Magnesium ferrite nanoparticles, with diameters around 25 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior, with a maximum magnetization of 16.2 emu/g, a coercive field of 22.1 Oe and a blocking temperature of 183.2 K. These MgFe2O4 nanoparticles were used to produce aqueous and solid magnetoliposomes, with sizes below 130 nm. The potential drug curcumin was successfully incorporated in these nanosystems, with high encapsulation efficiencies (above 89%). Interaction by fusion between both types of drug loaded magnetoliposomes (with or without PEGylation) and models of biological membranes was demonstrated, using FRET or fluorescence quenching assays. These results point to future applications of magnetoliposomes containing MgFe2O4 nanoparticles in cancer therapy, allowing combined magnetic hyperthermia and chemotherapy.
TypeArticle
URIhttp://hdl.handle.net/1822/56615
DOI10.1098/rsos.181017
ISSN2054-5703
Publisher versionhttp://rsos.royalsocietypublishing.org/content/5/10/181017
Peer-Reviewedyes
AccessOpen access
Appears in Collections:PHYSICS OF QUANTUM MATERIALS AND BIONANOSTRUCTURES (2018 - ...)

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