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|Title:||Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the mode drug curcumin|
|Author(s):||Cardoso, Beatriz D.|
Rio, Irina S. R.
Rodrigues, Ana Rita Oliveira
Fernandes, Francisca C. T.
Almeida, B. G.
Pereira, A. M.
Araújo, J. P.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
|Keywords:||magnesium ferrite nanoparticles|
|Journal:||Royal Society Open Science|
|Citation:||B. D. Cardoso, I. S. R. Rio, A. R. O. Rodrigues, F. C. T. Fernandes, B. G. Almeida, A. Pires, A. M. Pereira, J. P. Araújo, E. M. S. Castanheira, P. J. G. Coutinho, Royal Society Open Science, 5 (10) (2018) 181017|
|Abstract(s):||Magnesium ferrite nanoparticles, with diameters around 25 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior, with a maximum magnetization of 16.2 emu/g, a coercive field of 22.1 Oe and a blocking temperature of 183.2 K. These MgFe2O4 nanoparticles were used to produce aqueous and solid magnetoliposomes, with sizes below 130 nm. The potential drug curcumin was successfully incorporated in these nanosystems, with high encapsulation efficiencies (above 89%). Interaction by fusion between both types of drug loaded magnetoliposomes (with or without PEGylation) and models of biological membranes was demonstrated, using FRET or fluorescence quenching assays. These results point to future applications of magnetoliposomes containing MgFe2O4 nanoparticles in cancer therapy, allowing combined magnetic hyperthermia and chemotherapy.|
|Appears in Collections:||PHYSICS OF QUANTUM MATERIALS AND BIONANOSTRUCTURES (2018 - ...)|
Files in This Item:
|Magnesium_Ferrite_RSOS.pdf||Documento principal||1,38 MB||Adobe PDF||View/Open|
|Supplementary Material_Mg_Ferrite.pdf||Informação suplementar||288,38 kB||Adobe PDF||View/Open|
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