Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/56597

TitleUpdate on therapeutic approaches for rheumatoid arthritis
Author(s)Nogueira, E.
Gomes, Andreia C
Preto, Ana
Cavaco-Paulo, Artur
Issue date2016
PublisherBentham Science Publishers
JournalCurrent Medicinal Chemistry
CitationNogueira, E.; Gomes, Andreia; Preto, Ana; Cavaco-Paulo, Artur, Update on therapeutic approaches for rheumatoid arthritis. Current Medicinal Chemistry, 23(21), 2190-2203, 2016
Abstract(s)Rheumatoid arthritis is a common chronic inflammatory and destructive arthropathy that consumes considerable personal, social and economic costs. It consists a syndrome of pain, stiffness and symmetrical inflammation of the synovial membrane (synovitis) of freely moveable joints such as the knee (diarthrodial joints). Although the etiology of rheumatoid arthritis is unclear, the disease is characterized by inflammation of the synovial lining of diarthrodial joints, high synovial proliferation and an influx of inflammatory cells, macrophages and lymphocytes through angiogenic blood vessels. Disease-modifying antirheumatic drugs slow the disease progression and can induce disease remission in some patients. Methotrexate is the first line therapy, but if patients became intolerant to this drug, biologic agents should be used. The development of biological substances for the treatment of rheumatic conditions has been accompanied by ongoing health economic discussions regarding the implementation of these highly effective, but accordingly, highly priced drugs in the standard treatment guidelines of rheumatic diseases. In this way, more efficient strategies have to be identified. Despite numerous reviews in rheumatoid arthritis in the last years, this area is kept in constant development and updates are an urgent need to incorporate new advances in rheumatoid arthritis research. This review highlights the immunopathogenesis rationale for the current therapeutic strategies in rheumatoid arthritis.
TypeArticle
URIhttp://hdl.handle.net/1822/56597
DOI10.2174/0929867323666160506125218
ISSN0929-8673
e-ISSN1875-533X
Publisher versionhttp://benthamscience.com/journals/current-medicinal-chemistry/
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
DBio - Artigos/Papers

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