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TitleInjectable hydrogels as a delivery system for bone regeneration
Author(s)Pereira, Isabel
Rodrigues, C.
Rodrigues, A.
Oliveira, M.
Gama, F. M.
KeywordsBone regeneration
Synthetic bone substitute
Injectable bone substitute
Medical devices regulatory process
Issue date2017
PublisherWoodhead Publishing Limited
JournalWoodhead Publishing Series in Biomaterials
CitationPereira, Isabel; Rodrigues, A.; Rodrigues, A.; Manuela Oliveira; Gama, F. M., 9 - Injectable hydrogels as a delivery system for bone regeneration. In Lígia Rodrigues, Manuel Mota, Bioinspired Materials for Medical Applications, Woodhead Publishing, 2017. ISBN: 978-0-08-100741-9, 241-271.
Abstract(s)The worldwide incidence of bone disorders is increasing, mainly due to an ageing population. The lack of effective treatments is pushing the development of synthetic bone substitutes (SBSs). This chapter provides an overview of the currently available ceramic SBSs and describes the main advantages and limitations of commercially available ceramic-based injectable bone substitutes (IBSs), such as, bone cements and polymerceramic compositespastes and putties. The combination of injectable hydrogels and ceramic granules is emerging as a well-established trend. Particularly, in situ gelation hydrogels arise as a new IBSs generation. Herein, we present the recent progress in the development and application of hydrogel-based IBSs. Finally, the medical devices regulatory process is thoroughly discussed. Additionally, in view of the translation of IBSs into clinical practice, the main differences of the regulatory process in Europe and United States are highlighted.
TypeBook part
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:CEB - Livros e Capítulos de Livros / Books and Book Chapters

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