Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/56359

TitlePhotonic modulation of epidermal growth factor receptor halts receptor activation and cancer cell migration
Author(s)Botelho, Cláudia M.
Gonçalves, O.
Marques, R.
Thiagarajan, V.
Vorum, H.
Gomes, A.
Petersen-Neves, T.
Keywordsarrest cancer cell migration
EGF
EGFR
metastasis
photonic cancer therapy
protein photochemistry
Issue dateSep-2018
PublisherWiley-Blackwell
JournalJournal of Biophotonics
CitationBotelho, Cláudia M.; Gonçalves, O.; Marques, R.; Thiagarajan, V.; Vorum, H.; Gomes, A.; Petersen-Neves, T., Photonic modulation of epidermal growth factor receptor halts receptor activation and cancer cell migration. Journal of Biophotonics, 11(9), e201700323, 2018.
Abstract(s)Epidermal Growth Factor Receptor (EGFR) plays a key role in regulating cell survival, proliferation and migration, and its overexpression and activation has been correlated with cancer progression. Cancer therapies targeting EGFR have been applied in the clinic with some success. We show, by confocal microscopy analysis, that illumination of adenocarcinomic human alveolar basal epithelial cells (Human A549 EGFR biosensor cell line) with 280 nm at irradiance levels up to 20 times weaker than the UVB solar output for short periods of time (15-45 min) prevents EGF-mediated activation of EGFR located on the cell membrane, preventing or reducing cellular disaggregation, formation of filopodia and cell migration. This effect of UV light illumination was confirmed further in a functional scratch assay, and shown to be more effective than that of a specific EGFR-signaling inhibitor. This new photonic approach may be applicable to the treatment of various types of cancer, alone or in combination with other therapies.
TypeArticle
URIhttp://hdl.handle.net/1822/56359
DOI10.1002/jbio.201700323
ISSN1864-063X
e-ISSN1864-0648
Publisher versionhttp://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1864-0648
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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