Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/56325

TítuloTargeting of EGFR, VEGFR2 and Akt by engineered dual drug encapsulated mesoporous silica-gold nanoclusters sensitizes tamoxifen-resistant breast cancer
Autor(es)Kumar, B. N. P.
Puvvada, N.
Rajput, S.
Sarkar, S.
Mahto, K.
Yallapu, M.
Pathak, A.
Emdad, L.
Das, S. K.
Reis, R. L.
Kundu, Subhas C
Fisher, B.
Mandal, M.
Palavras-chaveAkt
EGFR
epigallocatechin gallate
silica-gold nanoclusters
VEGFR2
ZD6474
DataJul-2018
EditoraACS
RevistaMolecular Pharmaceutics
CitaçãoKumar B. N. P., Puvvada N., Rajput S., Sarkar S., Mahto K., Yallapu M., Pathak A., Emdad L., Das S. K., Reis R. L., Kundu S. C., Fisher B., Mandal M. Targeting of EGFR, VEGFR2 and Akt by engineered dual drug encapsulated mesoporous silica-gold nanoclusters sensitizes tamoxifen-resistant breast cancer, ACS Molecular Pharmaceutics, Vol. 15, Issue 7, pp. 2698–2713, doi:10.1021/acs.molpharmaceut.8b00218, 2018
Resumo(s)Tamoxifen administration enhanced overall disease-free survival and diminished mortality rates in cancer patients. However, patients with breast cancer often fail to respond for tamoxifen therapy due to the development of a drug-resistant phenotype. Functional analysis and molecular studies suggest that protein mutation and dysregulation of survival signaling molecules such as epidermal growth factor receptor, vascular endothelial growth factor receptor 2, and Akt contribute to tamoxifen resistance. Various strategies, including combinatorial therapies, show chemosensitize tamoxifen-resistant cancers. Based on chemotoxicity issues, researchers are actively investigating alternative therapeutic strategies. In the current study, we fabricate a mesoporous silica gold cluster nanodrug delivery system that displays exceptional tumor-targeting capability, thus promoting accretion of drug indices at the tumor site. We employ dual drugs, ZD6474, and epigallocatechin gallate (EGCG) that inhibit EGFR2, VEGFR2, and Akt signaling pathways since changes in these signaling pathways confer tamoxifen resistance in MCF 7 and T-47D cells. Mesoporous silica gold cluster nanodrug delivery of ZD6474 and EGCG sensitize tamoxifen-resistant cells to apoptosis. Western and immune-histochemical analyses confirmed the apoptotic inducing properties of the nanoformulation. Overall, results with these silica gold nanoclusters suggest that they may be a potent nanoformulation against chemoresistant cancers.
Tipoarticle
URIhttp://hdl.handle.net/1822/56325
DOI10.1021/acs.molpharmaceut.8b00218
ISSN1543-8384
Versão da editorahttps://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00218
Arbitragem científicayes
AcessorestrictedAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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