Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/56313

TítuloDesign of functional therapeutic deep eutectic solvents based on choline chloride and ascorbic acid
Autor(es)Silva, J. M.
Reis, R. L.
Paiva, A.
Duarte, A. R. C.
Palavras-chaveDrug delivery systems
Pharmaceuticals
Supercritical fluid sintering
Therapeutic deep eutectic solvents
DataJun-2018
EditoraACS
RevistaACS Sustainable Chemistry and Engineering
CitaçãoSilva J. M., Reis R. L., Paiva A., Duarte A. R. C. Design of functional therapeutic deep eutectic solvents based on choline chloride and ascorbic acid, ACS Sustainable Chem. Eng., Vol. 6, Issue 8, pp. 10355-10363, doi:10.1021/acssuschemeng.8b01687, 2018
Resumo(s)In this work, we report the preparation of novel therapeutic deep eutectic solvents (THEDES) based on choline chloride (CC) and ascorbic acid (AA), in which dexamethasone (DEX) was successfully solubilized. THEDES were synthesized and characterized for thermal behavior and polarized optic microscopy to confirm the formation of a eutectic mixture. The solubility profile of DEX solubilized in THEDES was greatly improved when compared with DEX in powder form. Additionally, the diffusion and permeability of DEX were also slightly increased. The antioxidant properties of AA were maintained up to 6 months when the compound is in THEDES form. Biological tests were also performed, and the results indicate that cell viability varies in a dose-dependent manner. After the half maximal effective concentration (EC50) was determined, a controlled drug delivery system was successfully developed by supercritical fluid sintering of a starch:poly-ε-caprolactone blend doped with THEDES containing solubilized DEX. The present study highlights the potential applicability of THEDES based on CC and AA in the pharmaceutical industry and/or tissue engineering (TE) applications.
Tipoarticle
URIhttp://hdl.handle.net/1822/56313
DOI10.1021/acssuschemeng.8b01687
ISSN2168-0485
Versão da editorahttps://pubs.acs.org/doi/10.1021/acssuschemeng.8b01687
Arbitragem científicayes
AcessorestrictedAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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