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TitleTissue engineering strategies for osteochondral repair
Author(s)Maia, F. Raquel
Carvalho, Mariana Rodrigues
Oliveira, J. M.
Reis, R. L.
KeywordsCell free strategies
Extracellular matrix mimicry
Osteochondral regeneration
Scaffold-free strategies
Issue date2018
JournalAdvances in Experimental Medicine and Biology
CitationMaia F. R., Carvalho M. R., Oliveira J. M., Reis R. L. Tissue Engineering Strategies for Osteochondral Repair, Osteochondral Tissue Engineering: Challenges, Current Strategies, and Technological Advances, pp. 353-371, doi:10.1007/978-3-319-76735-2_16, 2018
Abstract(s)Tissue engineering strategies have been pushing forward several fields in the range of biomedical research. The musculoskeletal field is not an exception. In fact, tissue engineering has been a great asset in the development of new treatments for osteochondral lesions. Herein, we overview the recent developments in osteochondral tissue engineering. Currently, the treatments applied in a clinical scenario have shown some drawbacks given the difficulty in regenerate a fully functional hyaline cartilage. Among the different strategies designed for osteochondral regeneration, it is possible to identify cell-free strategies, scaffold-free strategies and advanced strategies, where different materials are combined with cells. Cell-free strategies consist in the development of scaffolds in the attempt to better fulfill the requirements of the cartilage regeneration process. For that, different structures have been designed, from monolayers to multi-layered structures with the intent to mimic the osteochondral architecture. In the case of scaffold-free strategies, they took advantage on the extracellular matrix produced by cells. The last strategy relies in the development of new biomaterials capable of mimicking the extracellular matrix. This way, the cell growth, proliferation and differentiation at the lesion site is expedited, exploiting the self-regenerative potential of cells and its interaction with biomolecules. Overall, despite the difficulties associated with each approach, tissue engineering has been proven a valuable tool in the regeneration of osteochondral lesions, and together with the latest advances in the field, promises to revolutionize personalized therapies.
TypeBook part
Publisher version
AccessRestricted access (Author)
Appears in Collections:3B’s - Capítulos de Livros/Book Chapters

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