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TitleMagnetoliposomes for dual cancer therapy
Author(s)Rodrigues, Ana Rita Oliveira
Almeida, B. G.
Araújo, João P.
Queiroz, Maria João R. P.
Coutinho, Paulo J. G.
Castanheira, Elisabete M. S.
KeywordsMagnetic nanoparticles
Magnetic liposomes
Cancer therapy
Magnetic hyperthermia
Drug delivery
Smart nanocarriers
Issue dateMay-2018
Abstract(s)Liposomes can overcome many of the problems associated with other systems used in therapy, such as problems involving solubility, toxicity, pharmacokinetics, and in vivo stability. However, this system still presents some issues for in vivo application, namely its recognition and capture by the immune system and the location in therapeutic sites for drug release. In order to overcome these problems, magneto-sensitive liposomes have been proposed. The magnetic components allow the concentration of the liposomes in the desired area of the patient organs by magnetic forces. Therefore, a new therapy is emerging, involving the magnetically guided transport of drugs (most of them toxic and with systemic side effects), and focusing them in specific sites of the human body. Magneto-sensitive liposomes result from the encapsulation of magnetic nanoparticles into liposomes. The so-called magnetoliposomes combine the amazing physical properties of these two types of nanosystems and preserve the magnetic properties of the nanoparticles. This ideal nanocarrier can be used in a wide array of biomedical applications. In therapy, the most promising applications of magnetoliposomes are magnetic-guided drug delivery and hyperthermia. Furthermore, in diagnosis, magnetic nanoparticles have been used as contrast agents in magnetic resonance imaging. The magnetic nanoparticles can be either entrapped in liposomes, creating aqueous magnetoliposomes, or covered with a lipid bilayer, forming solid (or dry) magnetoliposomes. Both aqueous and solid magnetoliposomes have been used as nanocarriers for new and well-established anticancer drugs. This chapter describes the synthesis, characterization, and applications of magnetoliposomes in cancer therapy, both by antitumor drug delivery and hyperthermia, as well as the ability to attain magnetic guidance to the therapeutic sites of interest.
TypeBook part
DescriptionUncorrected proof
Publisher version
AccessRestricted access (UMinho)

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