Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/55880

TitleAntibacterial effect and biocompatibility of a novel nanostructured ZnO-coated gutta-percha cone for improved endodontic treatment
Author(s)Alves, M. J.
Grenho, L.
Lopes, Cláudia Jesus Ribeiro
Borges, Joel Nuno Pinto
Vaz, F.
Vaz, I. P.
Fernandes, M. H.
KeywordsAntibacterial activity
Ar-plasma treatment
Cytocompatibility
Gutta-percha cones
UV activation
ZnO thin films
Issue date2018
PublisherElsevier Ltd
JournalMaterials Science and Engineering: C
CitationM.J. Alves, L. Grenho, C. Lopes, J. Borges, F. Vaz, I.P. Vaz, M.H. Fernandes , Antibacterial effect and biocompatibility of a novel nanostructured ZnOcoated gutta-percha cone for improved endodontic treatment. Msc (2018), doi:10.1016/ j.msec.2018.07.045
Abstract(s)This work explored a novel approach to enhance the antibacterial activity of commercial Gutta-percha (GP) cones, the most commonly used core filling materials used in endodontic treatment. The reported procedure involved an argon (Ar) plasma treatment (PT) of the GP cone surface, followed by the deposition of a ZnO thin film by magnetron sputtering. The resulting surfaces were evaluated for surface topography, antibacterial activity against Enterococcus faecalis and Staphylococcus aureus, and cytocompatibility with human osteoblastic cells. GP cones treated with NaOCl, a routine chair-side protocol, were also tested as reference. The deposition of a ZnO film on pristine GP cones increased its antibacterial activity. Cones pre-treated with Ar-plasma (PT) and coated with the ZnO thin film presented significantly higher antibacterial activity than that observed on the pristine and, also, compared to the ZnO coated cones. The higher antibacterial activity of PT + ZnO cones appears related to the major effects induced by the PT pre-treatment on the cone surface endowing the deposited ZnO film with a homogeneous nanostructured topography that greatly improved surface reactivity. The modified GP cones maintained an appropriate cytocompatibility with human cells. This novel approach provides ready-to-use cones with enhanced antibacterial activity, improving a strict asepsis protocol during endodontic treatment and preventing secondary endodontic infections.
TypeArticle
URIhttp://hdl.handle.net/1822/55880
DOI10.1016/j.msec.2018.07.045
ISSN0928-4931
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CDF - GRF - Artigos/Papers (with refereeing)

Files in This Item:
File Description SizeFormat 
10.1016@j.msec.2018.07.045[4076].pdf
  Restricted access
6,52 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID