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TitleFunctionalization of silicone rubber surfaces towards biomedical applications
Author(s)Rodrigues, L. R.
Dourado, Fernando
Keywordsatom transfer radical polymerization
plasma treatment
polymer brushes
silicone rubber
surface modification
voice prostheses
Issue date2014
PublisherJohn Wiley & Sons Inc
CitationRodrigues, Lígia R.; Dourado, Fernando, Functionalization of silicone rubber surfaces towards biomedical applications. In Atul Tiwari, Mark D. Soucek, Concise Encyclopedia of High Performance Silicones, Hoboken, NJ: John Wiley & Sons, Inc., 2014. ISBN: 9781118938478, 111-122
Abstract(s)The surface of a biomaterial has been found to be of prime importance in determining the in vivo performance and host acceptance of the material. The biocompatibility of implantable devices remains a critical issue in limiting device longevity and functionality. Growing efforts have and are being made to further understand the interactions between biomaterials surface physicochemical and cell mediated processes, with the ultimate role of defining the major rules regulating the biomaterial biocompatibility. This review focuses on polydimethylsiloxane polymers, specifically silicone rubber, a well-known biomaterial for the production of prostheses that holds various attractive properties. Despite its widespread use, the extensive hydrophobicity of silicone rubber is disadvantageous and often demands further (surface) modification to improve its performance in vivo. Hydrophobic surfaces tend to adsorb proteins from the surrounding biological environment, subsequently triggering microbial adhesion and biofilm formation. Numerous strategies have been investigated to overcome foreign body reactions induced by the implanted devices. These strategies, their advantages and limitations, as well as state of the art concerning the multidisciplinary field of biomaterial surface modification are discussed.
TypeBook part
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:CEB - Livros e Capítulos de Livros / Books and Book Chapters

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