Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/55615
Título: | Co-delivery of two anti-HIV drug nanocrystals from electrospun nanofibers |
Autor(es): | Malta, Rafaela Neves, José das Sarmento, Bruno Machado, Raul Lúcio, M. Viseu, T. M. R. |
Palavras-chave: | HIV infection Tenofovir disoproxil fumarate (TDF) Emtricitabine (EMT) Electrospinning Polymeric nanofibers Controled drug delivery |
Data: | 5-Jul-2017 |
Resumo(s): | TRUVADA is the only medication approved by FDA for pre-exposure prophylaxis of the HIV infection. They are tablets with fixed dosages of two antiretroviral compounds for daily oral uptake: Tenofovir disoproxil fumarate (TDF) and Emtricitabine (EMT) that are reverse transcriptase inhibitors. Objectives: Incorporate TDF and EMT drugs in polymeric nanofibers produced by electrospinning; chosen polymers were polyoxyethilene (PEO) and polycaprolactone (PCL). Characterize the nanofibers and study the in vitro release profile of the drugs. Evaluate the possibility of a topical administration of the loaded fibers , by rectal or genital route, for HIV infection prophylaxis. |
Tipo: | Poster em conferência |
URI: | https://hdl.handle.net/1822/55615 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDF - FAMO - Outros Documentos/Other Documents (without refereeing) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Poster-Rafaela-final.pdf | 1,97 MB | Adobe PDF | Ver/Abrir |