Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/55193

TitleAgent-based model of diffusion of N-acyl homoserine lactones in a multicellular environment of Pseudomonas aeruginosa and Candida albicans
Author(s)Pérez-Rodríguez, Gael
Dias, Sónia
Pérez-Pérez, Martín
Fdez-Riverola, Florentino
Azevedo, Nuno Filipe Ribeiro Pinto Oliveira
Lourenço, Anália Maria Garcia
KeywordsCellular systems
quorum-sensing signalling
agent-based modelling
three-dimensional model representation
individual molecule simulation
Issue date2018
PublisherTaylor & Francis
JournalBiofouling: The Journal of Bioadhesion and Biofilm Research
CitationPérez-Rodríguez, Gael; Dias, Sónia; Pérez-Pérez, Martín; Fdez-Riverola, Florentino; Azevedo, Nuno F.; Lourenço, Anália, Agent-based model of diffusion of N-acyl homoserine lactones in a multicellular environment of Pseudomonas aeruginosa and Candida albicans. Biofouling - The Journal of Bioadhesion and Biofilm Research, 341(3), 335-345, 2018
Abstract(s)Experimental incapacity to track microbemicrobe interactions in structures like biofilms, and the complexity inherent to the mathematical modelling of those interactions, raises the need for feasible, alternative modelling approaches. This work proposes an agent-based representation of the diffusion of N-acyl homoserine lactones (AHL) in a multicellular environment formed by Pseudomonas aeruginosa and Candida albicans. Depending on the spatial location, C. albicans cells were variably exposed to AHLs, an observation that might help explain why phenotypic switching of individual cells in biofilms occurred at different time points. The simulation and algebraic results were similar for simpler scenarios, although some statistical differences could be observed (p<0.05). The model was also successfully applied to a more complex scenario representing a small multicellular environment containing C. albicans and P. aeruginosa cells encased in a 3-D matrix. Further development of this model may help create a predictive tool to depict biofilm heterogeneity at the single-cell level.
TypeArticle
URIhttp://hdl.handle.net/1822/55193
DOI10.1080/08927014.2018.1440392
ISSN0892-7014
e-ISSN1029-2454
Publisher versionhttp://www.tandfonline.com/action/journalInformation?journalCode=gbif20
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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