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|Title:||Ultrasound-assisted biosynthesis of novel methotrexate-conjugates|
|Author(s):||Noro, Jennifer Martins|
Reis, R. L.
|Citation:||Jennifer Noro; Reis, Rui L.; Cavaco-Paulo, Artur; Silva, Carla, Ultrasound-assisted biosynthesis of novel methotrexate-conjugates. Ultrasonics Sonochemistry, 48, 51-56, 2018|
|Abstract(s):||New methotrexate-acylglycerols and methotrexate-cyclodextrins (, and -CD) conjugates were obtained via esterification or transesterification reactions. All reactions were catalysed by esterases namely immobilized Lipase from Candida antarctica B and Lipase from Thermomyces lanuginosus. The use of ultrasound to assist the reactions revealed to be a key factor to obtain high conversion yields on both MTX conjugates. Transesterification reactions including long chain triacylglycerols were only successful when ultrasound was applied. In cyclodextrins esterification a higher number of MTX molecules was also linked to cyclodextrins when ultrasound was used. All the conjugates were characterized by MALDI-TOF and NMR spectroscopy.|
|Appears in Collections:||3B’s - Artigos em revistas/Papers in scientific journals|
CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series