Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/55082

TitleUltrasound-assisted biosynthesis of novel methotrexate-conjugates
Author(s)Noro, Jennifer Martins
Reis, R. L.
Cavaco-Paulo, Artur
Silva, Carla
KeywordsBiosynthesis
Lipases
Ultrasound
Methotrexate
triacylglycerols
cyclodextrins
Issue dateNov-2018
PublisherElsevier
JournalUltrasonics Sonochemistry
CitationJennifer Noro; Reis, Rui L.; Cavaco-Paulo, Artur; Silva, Carla, Ultrasound-assisted biosynthesis of novel methotrexate-conjugates. Ultrasonics Sonochemistry, 48, 51-56, 2018
Abstract(s)New methotrexate-acylglycerols and methotrexate-cyclodextrins (, and -CD) conjugates were obtained via esterification or transesterification reactions. All reactions were catalysed by esterases namely immobilized Lipase from Candida antarctica B and Lipase from Thermomyces lanuginosus. The use of ultrasound to assist the reactions revealed to be a key factor to obtain high conversion yields on both MTX conjugates. Transesterification reactions including long chain triacylglycerols were only successful when ultrasound was applied. In cyclodextrins esterification a higher number of MTX molecules was also linked to cyclodextrins when ultrasound was used. All the conjugates were characterized by MALDI-TOF and NMR spectroscopy.
TypeArticle
URIhttp://hdl.handle.net/1822/55082
DOI10.1016/j.ultsonch.2018.05.017
ISSN1350-4177
e-ISSN1350-4177
Publisher versionhttp://www.journals.elsevier.com/ultrasonics-sonochemistry/
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals
CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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