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TitleGenomic analysis of Acinetobacter baumannii prophages reveals remarkable diversity and suggests profound impact on bacterial virulence and fitness
Author(s)Costa, Ana Rita
Monteiro, Rodrigo
Azeredo, Joana
Issue date6-Jul-2017
CitationCosta, Ana Rita; Monteiro, Rodrigo; Azeredo, Joana, Genomic analysis of Acinetobacter baumannii prophages reveals remarkable diversity and suggests profound impact on bacterial virulence and fitness. Book of Abstracts of CEB Annual Meeting 2017. Braga, 6 July, 54, 2017. ISBN: 978-989-97478-8-3
Abstract(s)[Excerpt] Acinetobacter baumannii has been recently indicated by the World Health Organization (WHO) as the number one priority pathogen for research and development of new antibiotics. This is a direct consequence of the fast evolution of pathogenicity, and in particular of multidrug resistance, of this nosocomial pathogen. While the development of new antibiotics is critical, understanding the mechanisms behind the crescent pathogenicity of this bacterium is equally relevant. Often, resistance and other virulence elements of pathogenic bacteria are contained on highly mobile pieces of DNA that can easily spread to other bacteria by a process of horizontal gene transfer (HGT). Among mediators of HGT we find bacteriophages (phages), viruses of bacteria thought to be the most abundant entities on Earth. When infecting a bacterial host, phages may follow a lytic path in which they replicate inside the bacteria and cause cell lysis for progeny release, or they may follow a lysogenic life cycle where they integrate the host genome and replicate in synchrony. Phages opting for the lysogenic life cycle are known as temperate phages, or prophages when integrated in the bacterial genome. Under certain stimuli prophages can excise from the host genome, entering the lytic cycle and resulting in cell death and release of phage progeny. During excision, a process of specialized transduction may occur, where parts of the bacterial genome adjacent to the prophages may be erroneously excised with the prophage genome and introduced with the virion into a new host. Often these pieces of DNA offer advantageous features to the bacterial host, as exemplified by the well-known prophage-encoded Shiga toxin of Escherichia coli O157:H7. [...]
DescriptionBook of Abstracts of CEB Annual Meeting 2017
Publisher version
Appears in Collections:CEB - Resumos em Livros de Atas / Abstracts in Proceedings

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