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TitleBiotechnological applications of bacteriophages: state of the art
Author(s)Harada, Liliam K.
Silva, Erica C.
Campos, Welida F.
Del Fiol, Fernando S.
Vila, Marta M. D. C.
Dabrowska, Krystyna
Krylov, Victor N.
Balcão, Victor M.
Phage therapy
Phage display
Bacterial biosensing
Vaccine carriers
Gene delivery
Food biopreservation and safety
Biofilm control
Surface disinfection
Corrosion control
Structural and functional stabilization
Issue date2018
JournalMicrobiological Research
CitationHarada, Liliam K.; Silva, Erica C.; Campos, Welida F.; Del Fiol, Fernando S.; Vila, Marta; Dabrowska, Krystyna; Krylov, Victor N.; Balcão, Victor M., Biotechnological applications of bacteriophages: State of the art. Microbiological Research, 212-213, 38-58, 2018
Abstract(s)Bacteriophage particles are the most abundant biological entities on our planet, infecting specific bacterial hosts in every known environment and being major drivers of bacterial adaptive evolution. The study of bacteriophage particles potentially sheds light on the development of new biotechnology products. Bacteriophage therapy, although not new, makes use of strictly lytic phage particles as an alternative in the antimicrobial treatment of resistant bacterial infections and is being rediscovered as a safe method due to the fact that these biological entities devoid of any metabolic machinery do not have affinity to eukaryotic cells. Furthermore, bacteriophage-based vaccination is emerging as one of the most promising preventive strategies. This review paper discusses the biological nature of bacteriophage particles, their mode(s) of action and potential exploitation in modern biotechnology. Topics covered in detail include the potential of bacteriophage particles in human infections (bacteriophage therapy), nanocages for gene delivery, food biopreservation and safety, biocontrol of plant pathogens, phage display, bacterial biosensing devices, vaccines and vaccine carriers, biofilm and bacterial growth control, surface disinfection, corrosion control, together with structural and functional stabilization issues.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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