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TitleCarvacrol is highly disruptive against coagulase-negative staphylococci in in vitro biofilms
Author(s)Gaio, Vânia Silva
Lima, Cláudia Sofia Afonso de
Oliveira, Fernando Eduardo Freitas
França, Ângela Maria Oliveira Sousa
Cerca, Nuno
KeywordsAntimicrobial resistance
Nosocomial infections
Issue date2017
PublisherFuture Medicine Ltd
JournalFuture Microbiology
CitationGaio, Vania; Lima, C.; Oliveira, Fernando E.; França, Angela; Cerca, Nuno, Carvacrol is highly disruptive against coagulase-negative staphylococci in in vitro biofilms. Future Microbiology, 12(16), 1487-1496, 2017
Abstract(s)Aim: To evaluate the antimicrobial activity of carvacrol against stationary-phase planktonic and biofilm cells of coagulase-negative staphylococci and comparison to traditional antistaphylococcal antibiotics. MATERIALS & METHODS: The antimicrobial effect of carvacrol and antibiotics against planktonic and biofilm cells were assessed through quantification of the number of culturable and/or viable cells. Confocal laser scanning microscopy was used to evaluate the effect of carvacrol on the biofilm structure. RESULTS: A concentration of 4 mM of carvacrol demonstrated a potent antimicrobial effect, vastly superior than ciprofloxacin, rifampicin, gentamicin and vancomycin, both in planktonic and biofilm cells. CONCLUSION: Carvacrol is a potential antimicrobial agent, which applicability for the prevention and/or treatment of coagulase-negative staphylococci biofilm-associated infections is worthwhile investigating in more detail.
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Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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