Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/54502

TítuloDesigning biomaterials based on biomineralization for bone repair and regeneration
Autor(es)Leonor, I. B.
Rodrigues, A. I.
Reis, R. L.
Palavras-chaveBioactive Ceramics
bone regeneration
In vitro Bioactivity
Self-mineralized polymers
Biodegradable polymer
Functional groups
Simulated body fluid
CitaçãoLeonor I. B., Rodrigues A. I., Reis R. L. (2015) Designing biomaterials based on biomineralization for bone repair and regeneration, Biomineralization and Biomaterials: Fundamentals and Applications, pp. 377-404, doi:10.1016/B978-1-78242-338-6.00014-4.
Resumo(s)The research work presented in this chapter highlights the importance of under- standing the surface chemistry of biomaterials, as well as the main mechanism for apatite formation, which provides the fundamental principles and tools for designing new bioactive materials. These fundamental mechanisms of bioactive ceramics are believed to open a new avenue for future breakthroughs for clinical biointeractive materials with novel physical, chemical, and biological functions. Here, it was demon- strated that any organic polymer can also exhibit bioactivity if its surface is modified with a functional group effective in apatite nucleation. These new types of bioactive materials are expected to play an important role in bone replacement and regeneration. Therefore, it can be concluded that the key point lies in designing an organized func- tionalized surface to control the mechanisms of apatite nucleation. Additionally, we highlight that controlling the material properties by functionalization can work as an approach to control cell proliferation and differentiation.
Versão da editorahttps://www.elsevier.com/books/biomineralization-and-biomaterials/aparicio/978-1-78242-338-6
Arbitragem científicayes
Aparece nas coleções:3B’s - Capítulos de Livros/Book Chapters

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