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|Title:||Expression, purification and in vitro biological activity from human recombinant BMP-2 produced by a novel approach|
|Author(s):||Bessa, Paulo C.|
Pedro, A. P.
Reis, R. L.
|Abstract(s):||Bone morphogenetic proteins have promoted great biomedical interest due to their ability in inducing new bone formation when used as powerful osteoinductive components of several late-stage bone grafting products. Recombinant human bone morphogenetic protein-2 (rhBMP-2) is obtained from mammalian cell expressing systems in low amounts or from bacteria inclusion bodies after timeconsuming refolding methods. Thus, there is a need to establish novel approaches for producing rhBMP-2 in high yields by simple and cheap procedures.|
|Appears in Collections:||DBio - Comunicações/Communications in Congresses|
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