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https://hdl.handle.net/1822/53991
Título: | Metabolite secretion in microorganisms: the theory of metabolic overflow put to the test |
Autor(es): | Pinu, Farhana R. Granucci, Ninna Daniell, James Han, Ting-Li Carneiro, Sónia Rocha, I. Nielsen, Jens Villas-Boas, Silas G. |
Palavras-chave: | Microbial metabolism Microorganisms Active efflux Secretion Metabolic engineering Metabolic modelling Systems biology Metabolic modeling |
Data: | Abr-2018 |
Editora: | Springer Nature |
Revista: | Metabolomics |
Citação: | Pinu, Farhana R.; Granucci, Ninna; Daniell, James; Han, Ting-Li; Carneiro, Sónia; Rocha, Isabel; Nielsen, Jens; Villas-Boas, Silas G., Metabolite secretion in microorganisms: the theory of metabolic overflow put to the test. Metabolomics, 14(4), 43-43, 2018 |
Resumo(s): | Introduction Microbial cells secrete many metabolites during growth, including important intermediates of the central carbon metabolism. This has not been taken into account by researchers when modeling microbial metabolism for metabolic engineering and systems biology studies. Materials and Methods The uptake of metabolites by microorganisms is well studied, but our knowledge of how and why they secrete different intracellular compounds is poor. The secretion of metabolites by microbial cells has traditionally been regarded as a consequence of intracellular metabolic overflow. Conclusions Here, we provide evidence based on time-series metabolomics data that microbial cells eliminate some metabolites in response to environmental cues, independent of metabolic overflow. Moreover, we review the different mechanisms of metabolite secretion and explore how this knowledge can benefit metabolic modeling and engineering. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/53991 |
DOI: | 10.1007/s11306-018-1339-7 |
ISSN: | 1573-3890 |
e-ISSN: | 1573-3882 |
Versão da editora: | http://www.springer.com/journal/11306/about |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_47518_1.pdf | 3,99 MB | Adobe PDF | Ver/Abrir |