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|Title:||Fruit-based carbon dots as fluorescent probes: in vitro and in vivo toxicity evaluation|
Sárria, Marisa P.
Peixoto, J. M.
|Citation:||Dias, Cindy; Sárria, Marisa P.; Vasimalai, Nagamalai; Vilas-Boas, Vânia; Peixoto, J. M.; Espiña, Begoña, Fruit-based carbon dots as fluorescent probes: in vitro and in vivo toxicity evaluation. MNE2017 - 43rd International Conference on Micro and Nanoengineering (Conference Booklet). No. PO131, Braga, Portugal, Sep. 18-22, 2017.|
|Abstract(s):||New solutions for biomedical purposes are a major focus of interest for the development of new nanomaterials. In comparison to traditional metal-based quantum dots, photoluminescent carbon-dots are greater in terms of aqueous solubility, chemical inertness, simple modification and fluorescent proprieties. In this work C-dots derived from kiwi and avocado and synthesized using a green method were evaluated for their toxicity and bioimaging in vitro and in vivo. Normal and cancer cells lines, and zebrafish embryos were used as in vitro an in vivo models, respectively, either for toxicological profile and confocal imaging. Both C-dots showed toxicity profiles in the range of mg/mL concentrations inducing delays in zebrafish embryos development. Concentrations of kiwi and avocado C-dots used for confocal bioimaging were adjusted below the NOAEL accordingly.|
|Description:||MNE2017 - 43rd International Conference on Micro and Nanoengineering (Conference Booklet)|
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|document_47499_2.pdf||Cover||37,35 kB||Adobe PDF||View/Open|
|document_47499_1.pdf||Abstract||112,96 kB||Adobe PDF||View/Open|
|poster20MNE_Cindy.pdf||Poster||4,62 MB||Adobe PDF||View/Open|