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TitleCutting edge: IFN-γ regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection
Author(s)Cruz, Andrea
Khader, Shabaana A.
Torrado, Egídio
Fraga, Alexandra G.
Pearl, John E.
Pedrosa, Jorge
Cooper, Andrea M.
Castro, António G.
CD4 T Cells
Mycobacterial Infection
Issue date2006
PublisherAmerican Association of Immunologists
JournalThe Journal of Immunology
Citation"The Journal of Immunology". ISSN 0022-1767. 177 (2006) 1416-1420.
Abstract(s)T cell responses are important to the control of infection but are deleterious if not regulated. IFN-γ-deficient mice infected with mycobacteria exhibit enhanced accumulation of activated effector T cells and neutrophils within granulomatous lesions. These cells do not control bacterial growth and compromise the integrity of the infected tissue. We show that IFN-γ-deficient mice have increased numbers of IL-17-producing T cells following infection with Mycobacterium bovis bacille Calmette Gue´rin. Furthermore, exogenous IFN-γ increases IL-12 and decreases IL-23 production by bacille Calmette Gue´rin-infected bone marrow-derived dendritic cells and reduces the frequency of IL-17-producing T cells induced by these bone marrow-derived dendritic cells. These data support the hypothesis that, during mycobacterial infection, both IFN-γ- and IL-17-producing T cells are induced, but that IFN-γ serves to limit the IL-17-producing T cell population. This counterregulation pathway may be an important factor in limiting mycobacterially associated immune- mediated pathology.
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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