Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/52212

TitlePatterns of default mode network deactivation in obsessive compulsive disorder
Author(s)Gonçalves, Óscar F.
Soares, José Miguel Montenegro
Carvalho, Sandra
Leite, Jorge
Costa, Ana Ganho Ávila
Fernandes-Gonçalves, Ana
Pocinho, Fernando
Carracedo, Angel
Sampaio, Adriana
Issue date2017
PublisherNature Publishing Group
JournalScientific Reports
Abstract(s)The objective of the present study was to research the patterns of Default Mode Network (DMN) deactivation in Obsessive Compulsive Disorder (OCD) in the transition between a resting and a non-rest emotional condition. Twenty-seven participants, 15 diagnosed with OCD and 12 healthy controls (HC), underwent a functional neuroimaging paradigm in which DMN brain activation in a resting condition was contrasted with activity during a non-rest condition consisting in the presentation of emotionally pleasant and unpleasant images. Results showed that HC, when compared with OCD, had a significant deactivation in two anterior nodes of the DMN (medial frontal and superior frontal) in the non-rest pleasant stimuli condition. Additional analysis for the whole brain, contrasting the resting condition with all the non-rest conditions grouped together, showed that, compared with OCD, HC had a significantly deactivation of a widespread brain network (superior frontal, insula, middle and superior temporal, putamen, lingual, cuneus, and cerebellum). Concluding, the present study found that OCD patients had difficulties with the deactivation of DMN even when the non-rest condition includes the presentation of emotional provoking stimuli, particularly evident for images with pleasant content.
TypeArticle
URIhttp://hdl.handle.net/1822/52212
DOI10.1038/srep44468
ISSN2045-2322
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CIPsi - Artigos (Papers)

Files in This Item:
File Description SizeFormat 
Patterns of Default Mode Network Deactivation in Obsessive Compulsive Disorder.pdf524,34 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID