Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/52206

TitleGray matter abnormalities in the inhibitory circuitry of young binge drinkers: a voxel-based morphometry study
Author(s)Sousa, Sónia Silva
Sampaio, Adriana
Marques, Paulo César Gonçalves
Gonçalves, Óscar F.
Crego, Alberto
KeywordsBinge drinking
Gray matter
Inhibitory control
Self-regulation
Impulsivity
Adolescence
College-students
Voxel-based morphometry
Issue dateSep-2017
PublisherFrontiers Media
JournalFrontiers in Psychology
Abstract(s)Binge drinking (BD) is defined as a pattern of high alcohol intake in a short time followed by periods of abstinence. This behavior is very common in adolescence, a developmental stage characterized by the maturation of the prefrontal and striatal networks, important circuits underlying the capacity to control and regulate the behavior. In this study, we conducted a voxel-based morphometry (VBM) analysis, using a region of interest (ROI) analysis of brain regions associated with inhibitory control and self-regulatory processes, in a group of 36 young college students, 20 binge drinkers (BDs) and 16 alcohol abstinent controls (AAC). Results showed increased gray matter (GM) densities in the left middle frontal gyrus in BDs, when compared with alcohol abstinent controls. Additionally, a ROI-based Pearson analysis documented positive correlations between the left middle frontal gyrus GM densities and the self-control subscale of the Barratt Impulsiveness Scale (BIS), in the BD group. These findings highlight abnormalities in core brain regions associated with self-regulatory processes in the BD group.
TypeArticle
URIhttp://hdl.handle.net/1822/52206
DOI10.3389/fpsyg.2017.01567
ISSN1664-1078
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CIPsi - Artigos (Papers)
ICVS - Artigos em Revistas Internacionais com Referee


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