Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/52173

TitleGray matter morphological alteration in Obsessive Compulsive Disorder: evidence for an inhibitory control and emotional regulation disorder
Author(s)Gonçalves, Óscar F.
Carvalho, Sandra
Leite, Jorge
Fernandes-Gonçalves, Ana
Carracedo, Angel
Sampaio, Adriana
KeywordsNeuroimaging
Obsessive Compulsive Disorder
Brain volume
Brain shape
Inhibitory control
Emotional regulation
Issue date2016
PublisherHarvard University. Principles and Practice of Clinical Research (PPCR)
JournalPrinciples and Practice of Clinical Research
CitationGonçalves, O. F., Carvalho, S., Leite, J., Fernandes-Gonçalves, A., Carracedo, A., & Sampaio, A. (2016). Gray Matter Morphological Alteration in Obsessive Compulsive Disorder: Evidence for an Inhibitory Control and Emotional Regulation Disorder. Principles and Practice of Clinical Research Journal, 2, 2
Abstract(s)The integration of obsessive compulsive disorders (OCD) in the Obsessive Compulsive and Related Disorders cluster, while emphasizing the centrality of inhibitory control and repetitive behaviors may fail to fully acknowledge the existence of significant affective and other cognitive impairments. The objective of this paper is to present examples on available gray matter imaging studies and meta-analyses that may help understanding cognitive and emotional related factors implicated in OCD. Building on these studies, OCD seems to be a disorder of both inhibitory control and emotional regulation. Volumetric and shape abnormalities in different brain territories of the prefrontal cortex, orbitofrontal cortex, thalamus, striate and cerebellum may contribute to impairments in inhibitory control. On the other side, gray matter shape and volume alterations in regions such as the anterior cingulate, insula, amygdala and supramarginal gyrus may contribute to difficulties in emotional regulation. Beyond this inhibitory control – emotional regulation dichotomy, there are other psychological impairments that may be associated with gray matter alterations. For example, difficulties in memory monitoring may be sustained by shape and volumetric alterations in the dorso-lateral prefrontal cortex and the hippocampus. Additionally, visual-spatial impairments may be explained by gray matter shape and volume alterations in the superior parietal and occipital lobes as well as the precuneus. Overall the research confirms changes in volume and shape in multiple cortical and subcortical regions that can help explaining the complexity of OCD symptomatology and the diversity of OCD endophenotypes. Additionally, the evidence from brain shape anomalies may suggest the additional possibility of neurodevelopmental changes associated with the pathogenesis of OCD.
TypeArticle
URIhttp://hdl.handle.net/1822/52173
e-ISSN2378-1890
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CIPsi - Artigos (Papers)


Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID