Book of the 1st Proteome 2 Gene 2 Protein (P2G2P) Hands-On Course

Abstract

[Excerpt] The emergence of proteomics, the large-scale analysis of proteins, has been inspired by the awareness that the final product of a gene is inherently more complex and closer to function than the gene itself [1]. Today it is well recognized that any given genome can potentially give rise to an infinite number of proteomes. This happens because the proteome of any biological sample (e.g., cell, tissue, organ, organism, microbial consortium, etc) is dynamic, reflecting the immediate environment in which it is studied. Within a biological system, proteins can be synthesized, degraded, modified by post-translational modifications or undergo translocations in response to internal or external stimuli [1]. Thus, analyzing the proteome of a biological sample is a “snapshot” of the protein environment at that particular given time [1]. [...]