Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/51802

TitlePRP for degenerative cartilage disease: a systematic review of clinical studies
Author(s)Laver, Lior
Marom, Niv
Dnyanesh, Lad
Mei-Dan, Omer
Espregueira-Mendes, João
Gobbi, Alberto
KeywordsPlatelet-rich plasma
PRP
Osteoarthritis
Cartilage
Hyaluronic acid
Injections
Issue date2017
PublisherSAGE Publications
JournalCartilage
CitationLaver, L., Marom, N., Dnyanesh, L., Mei-Dan, O., Espregueira-Mendes, J., & Gobbi, A. (2017). PRP for degenerative cartilage disease: a systematic review of clinical studies. Cartilage, 8(4), 341-364.
Abstract(s)Objective: To explore the utilization of platelet-rich plasma (PRP) for degenerative cartilage processes and evaluate whether there is sufficient evidence to better define its potential effects. Design: Systematic literature reviews were conducted in PubMed/MEDLINE and Cochrane electronic databases till May 2015, using the keywords "platelet-rich plasma OR PRP OR autologous conditioned plasma OR ACP AND cartilage OR chondrocyte OR chondrogenesis OR osteoarthritis (OA) OR arthritis." Results: The final result yielded 29 articles. Twenty-six studies examined PRP administration for knee OA and 3 involved PRP administration for hip OA. The results included 9 prospective randomized controlled trials (RCTs) (8 knee and 1 hip), 4 prospective comparative studies, 14 case series, and 2 retrospective comparative studies. Hyaluronic acid (HA) was used as a control in 11 studies (7 RCTs, 2 prospective comparative studies, and 2 retrospective cohort). Overall, all RCTs reported on improved symptoms compared to baseline scores. Only 2 RCTs-one for knee and one for hip-did not report significant superiority of PRP compared to the control group (HA). Nine out of 11 HA controlled studies showed significant better results in the PRP groups. A trend toward better results for PRP injections in patients with early knee OA and young age was observed; however, lack of uniformity was evident in terms of indications, inclusion criteria, and pathology definitions in the different studies. Conclusion: Current clinical evidence supports the benefit in PRP treatment for knee and hip OA, proven to temporarily relieve pain and improve function of the involved joint with superior results compared with several alternative treatments. Further research to establish the optimal preparation protocol and characteristics of PRP injections for OA is needed.
TypeArticle
URIhttp://hdl.handle.net/1822/51802
DOI10.1177/1947603516670709
ISSN1947-6035
Publisher versionhttp://journals.sagepub.com/doi/10.1177/1947603516670709
Peer-Reviewedyes
AccessRestricted access (Author)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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