Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/51555

TitleTau-dependent suppression of adult neurogenesis in the stressed hippocampus
Author(s)Dioli, Chrysoula
Patrício, P.
Trindade, R.
Pinto, L. G.
Silva, J. M.
Morais, M.
Ferreiro, E.
Borges, S.
Mateus-Pinheiro, A.
Rodrigues, A. J.
Sousa, Nuno
Peixoto, João Miguel Seiça Bessa
Pinto, Luísa
Sotiropoulos, I.
Issue date28-May-2017
PublisherNature Publishing Group
JournalMolecular Psychiatry
CitationDioli, C., Patrício, P., Trindade, R., Pinto, L. G., Silva, J. M., Morais, M., ... & Sousa, N. (2017). Tau-dependent suppression of adult neurogenesis in the stressed hippocampus. Molecular psychiatry, 22(8), 1110
Abstract(s)Stress, a well-known sculptor of brain plasticity, is shown to suppress hippocampal neurogenesis in the adult brain; yet, the underlying cellular mechanisms are poorly investigated. Previous studies have shown that chronic stress triggers hyperphosphorylation and accumulation of the cytoskeletal protein Tau, a process that may impair the cytoskeleton-regulating role (s) of this protein with impact on neuronal function. Here, we analyzed the role of Tau on stress-driven suppression of neurogenesis in the adult dentate gyrus (DG) using animals lacking Tau (Tau-knockout; Tau-KO) and wild-type (WT) littermates. Unlike WTs, Tau-KO animals exposed to chronic stress did not exhibit reduction in DG proliferating cells, neuroblasts and newborn neurons; however, newborn astrocytes were similarly decreased in both Tau-KO and WT mice. In addition, chronic stress reduced phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR)/glycogen synthase kinase-3 beta (GSK3 beta)/beta-catenin signaling, known to regulate cell survival and proliferation, in the DG of WT, but not Tau-KO, animals. These data establish Tau as a critical regulator of the cellular cascades underlying stress deficits on hippocampal neurogenesis in the adult brain.
TypeArticle
Descriptionuncorrected proof
URIhttp://hdl.handle.net/1822/51555
DOI10.1038/mp.2017.103
ISSN1359-4184
Publisher versionhttps://www.nature.com/articles/mp2017103
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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