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https://hdl.handle.net/1822/51555
Título: | Tau-dependent suppression of adult neurogenesis in the stressed hippocampus |
Autor(es): | Dioli, Chrysoula Patrício, P. Trindade, R. Pinto, L. G. Silva, J. M. Morais, M. Ferreiro, E. Borges, S. Mateus-Pinheiro, A. Rodrigues, A. J. Sousa, Nuno Peixoto, João Miguel Seiça Bessa Pinto, Luísa Sotiropoulos, I. |
Data: | 28-Mai-2017 |
Editora: | Nature Publishing Group |
Revista: | Molecular Psychiatry |
Citação: | Dioli, C., Patrício, P., Trindade, R., Pinto, L. G., Silva, J. M., Morais, M., ... & Sousa, N. (2017). Tau-dependent suppression of adult neurogenesis in the stressed hippocampus. Molecular psychiatry, 22(8), 1110 |
Resumo(s): | Stress, a well-known sculptor of brain plasticity, is shown to suppress hippocampal neurogenesis in the adult brain; yet, the underlying cellular mechanisms are poorly investigated. Previous studies have shown that chronic stress triggers hyperphosphorylation and accumulation of the cytoskeletal protein Tau, a process that may impair the cytoskeleton-regulating role (s) of this protein with impact on neuronal function. Here, we analyzed the role of Tau on stress-driven suppression of neurogenesis in the adult dentate gyrus (DG) using animals lacking Tau (Tau-knockout; Tau-KO) and wild-type (WT) littermates. Unlike WTs, Tau-KO animals exposed to chronic stress did not exhibit reduction in DG proliferating cells, neuroblasts and newborn neurons; however, newborn astrocytes were similarly decreased in both Tau-KO and WT mice. In addition, chronic stress reduced phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR)/glycogen synthase kinase-3 beta (GSK3 beta)/beta-catenin signaling, known to regulate cell survival and proliferation, in the DG of WT, but not Tau-KO, animals. These data establish Tau as a critical regulator of the cellular cascades underlying stress deficits on hippocampal neurogenesis in the adult brain. |
Tipo: | Artigo |
Descrição: | uncorrected proof |
URI: | https://hdl.handle.net/1822/51555 |
DOI: | 10.1038/mp.2017.103 |
ISSN: | 1359-4184 |
Versão da editora: | https://www.nature.com/articles/mp2017103 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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mp2017103.pdf | 4,69 MB | Adobe PDF | Ver/Abrir |