Please use this identifier to cite or link to this item:

TitleTau-dependent suppression of adult neurogenesis in the stressed hippocampus
Author(s)Dioli, Chrysoula
Patrício, P.
Trindade, R.
Pinto, L. G.
Silva, J. M.
Morais, M.
Ferreiro, E.
Borges, S.
Mateus-Pinheiro, A.
Rodrigues, A. J.
Sousa, Nuno
Peixoto, João Miguel Seiça Bessa
Pinto, Luísa
Sotiropoulos, I.
Issue date28-May-2017
PublisherNature Publishing Group
JournalMolecular Psychiatry
CitationDioli, C., Patrício, P., Trindade, R., Pinto, L. G., Silva, J. M., Morais, M., ... & Sousa, N. (2017). Tau-dependent suppression of adult neurogenesis in the stressed hippocampus. Molecular psychiatry, 22(8), 1110
Abstract(s)Stress, a well-known sculptor of brain plasticity, is shown to suppress hippocampal neurogenesis in the adult brain; yet, the underlying cellular mechanisms are poorly investigated. Previous studies have shown that chronic stress triggers hyperphosphorylation and accumulation of the cytoskeletal protein Tau, a process that may impair the cytoskeleton-regulating role (s) of this protein with impact on neuronal function. Here, we analyzed the role of Tau on stress-driven suppression of neurogenesis in the adult dentate gyrus (DG) using animals lacking Tau (Tau-knockout; Tau-KO) and wild-type (WT) littermates. Unlike WTs, Tau-KO animals exposed to chronic stress did not exhibit reduction in DG proliferating cells, neuroblasts and newborn neurons; however, newborn astrocytes were similarly decreased in both Tau-KO and WT mice. In addition, chronic stress reduced phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR)/glycogen synthase kinase-3 beta (GSK3 beta)/beta-catenin signaling, known to regulate cell survival and proliferation, in the DG of WT, but not Tau-KO, animals. These data establish Tau as a critical regulator of the cellular cascades underlying stress deficits on hippocampal neurogenesis in the adult brain.
Descriptionuncorrected proof
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
mp2017103.pdf4,69 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID