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|Title:||Bioactivity of glycolipopeptide cell-bound biosurfactants against skin pathogens|
Ferreira, Débora Carina Gonçalves Abreu
Cruz, J. M.
Moldes, A. B.
Rodrigues, L. R.
|Journal:||International Journal of Biological Macromolecules|
|Citation:||Vecino, Xanel; Rodríguez-López, L.; Ferreira, Débora; Cruz, J. M.; Moldes, A. B.; Rodrigues, Lígia R., Bioactivity of glycolipopeptide cell-bound biosurfactants against skin pathogens. International Journal of Biological Macromolecules, 109, 971-979, 2018|
|Abstract(s):||The antimicrobial and anti-adhesive activities of the cell-bound biosurfactants, produced by Lactobacillus pentosus (PEB), characterized as glycolipopeptide macromolecules, were evaluated against several microorganisms present in the skin microflora, envisaging its potential use as a natural ingredient in cosmetic and personal care formulations. Their performance was compared with another cell-bound biosurfactants also characterized as glycolipopeptides produced by Lactobacillus paracasei (PAB). At concentrations of 50 mg/mL, the PEB showed an important antimicrobial activity against Pseudomonas aeruginosa (85% when extracted with phosphate buffer (PB) and 100% when extracted with phosphate buffer saline (PBS)), Streptococcus agalactiae (100% for both extracts), Staphylococcus aureus (67% when extracted with PBS and 100% when extracted with PB), Escherichia coli (72% when extracted with PB and 89% when extracted with PBS), Streptococcus pyogenes (about 85% for both extracts) and Candida albicans (around 70% for both extracts), comparable with that obtained for the PAB. However, at lower concentrations the PAB exhibited in general higher antimicrobial activities. Biosurfactants produced by both microorganisms also showed significant anti-adhesive properties against all the microorganisms under study, except for E. coli and C. albicans (less than 30%). Overall, these cell-bound biosurfactants could be used as potential antimicrobial and anti-adhesive agents in cosmetic and pharmaceutical formulations.|
|Description:||"Available online 21 November 2017"|
|Appears in Collections:||CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series|