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dc.contributor.authorKook, Yeon Jipor
dc.contributor.authorTian, Jingwenpor
dc.contributor.authorJeon, Yoo Shinpor
dc.contributor.authorChoi, Min Jungpor
dc.contributor.authorSong, Jeong Eunpor
dc.contributor.authorPark, Chan Humpor
dc.contributor.authorReis, R. L.por
dc.contributor.authorKhang, Gilsonpor
dc.identifier.citationKook Y. J., Tian J., Jeon Y. S., Choi M. J., Song J. E., Park C. H., Reis R. L., Khang G. Nature-derived epigallocatechin gallate/duck’s feet collagen/hydroxyapatite composite sponges for enhanced bone tissue regeneration, Journal Of Biomaterials Science-polymer Edition, Vol. -, Issue -, pp. 1-13, doi:10.1080/09205063.2017.1414480, 2018por
dc.description.abstractScaffolds mimicking structural and chemical characteristics of the native bone tissues are critical for bone tissue engineering. Herein, we have developed and characterized epigallocatechin gallate/duck's feet collagen/hydroxyapatite (EGCG/DC/HAp) composite sponges that enhanced the bone tissue regeneration. The three-dimensional composite sponges were synthesized by loading various amounts (i.e. 1, 5 and 10 μM) of EGCG to duck feet derived collagen followed by freeze-drying and then coating with hydroxyapatite. Several measuremental techniques were employed to examine the properties of the as-fabricated composite sponges including morphology and structure, porosity, compressive strength, etc. and as well compared with pristine duck feet derived collagen. SEM observations of EGCG/DC/HAp sponges showed the formation of a highly porous collagen matrix with EGCG embodiment. The porosity and pore size of sponges were found to increase by high EGCG content. The compressive strength was calculated as 3.54 ± 0.04, 3.63 ± 0.03, 3.89 ± 0.05, 4.047 ± 0.05 MPa for 1, 5 and 10 μM EGCG/DC/HAp sponges, respectively. Osteoblast-like cell (BMSCs isolated from rabbit) culture and in vivo experiments with EGCG/DC/HAp sponges implanted in nude mouse followed by histological staining showed enhanced cell internalization and attachment, cell proliferation, alkaline phosphatase expressions, indicating that EGCG/DC/HAp sponges have ahigh biocompatibility. Moreover, highEGCG content in the EGCG/DC/HAp sponges have led to increased cellular behavior. Collectively, the 5 μM of EGCG/DC/HAp sponges were suggested as the potential candidates for bone tissue regeneration.por
dc.description.sponsorshipThis research was supported by Technology Commercialization Support Program [grant number 814005-03-3-HD020], MIFAFF; and Basic Science Research Program [grant number NRF2017R1A2B3010270] through the National Research Foundation of Korea, Ministry of Science, ICT and Future Planning, Republic of Korea.por
dc.publisherTaylor and Francispor
dc.subjectBone marrow stromal cells (BMSCs)por
dc.subjectBone regenerationpor
dc.subjectDucks feet collagen (DC)por
dc.subjectEpigallocatechin gallate (EGCG)por
dc.subjectHydroxyapatite (HAp)por
dc.titleNature-derived epigallocatechin gallate/duck’s feet collagen/hydroxyapatite composite sponges for enhanced bone tissue regenerationpor
dc.subject.wosScience & Technologypor
sdum.journalJournal of Biomaterials Science. Polymer Editionpor
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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