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TitleBone turnover markers in sheep and goat: a review of the scientific literature
Author(s)Camassa, José A.
Diogo, Camila C.
Sousa, Cristina P.
Azevedo, Jorge T.
Viegas, Carlos A.
Reis, R. L.
Dourado, N.
Dias, Isabel R.
KeywordsBone formation markers
Bone resorption markers
Bone metabolism
Small ruminants
Issue dateMar-2017
PublisherAcademia Brasileira de Ciências
JournalAnnals of the Brazilian Academy of Sciences
CitationCamassa J. A., Diogo C. C., Sousa C. P., Azevedo J. T., Viegas C. A., Reis R. L., Dourado N., Dias I. R. Bone turnover markers in sheep and goat: A review of the scientific literature, Annals of the Brazilian Academy of Sciences, Vol. 89, Issue 1, pp. 231-245, doi:10.1590/0001-3765201720160407, 2017
Abstract(s)Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this review was to structure the available information on the use of BTMs in studies on small ruminants, especially for monitoring their variations related to diet, exercise, gestation and metabolic lactation state, circadian and seasonal variations, and also during skeletal growth. Pre-clinical and translational studies using BTMs with sheep and goats as animal models in orthopaedic research studies to help in the evaluation of the fracture healing process and osteoporosis research are also described in this review. The available information from the reviewed studies was systematically organized in order to highlight the most promising BTMs in small ruminant research, as well as provide a wide view of the use of sheep and goat as animal models in orthopaedic research, type of markers and commercial assay kits with cross-reactivity in sheep and goat, method of sample and storage of serum and urine for bone turnover markers determination and the usefulness and limitations of bone turnover markers in the different studies, therefore an effective tool for researchers that seek answers to different questions while using BTMs in small ruminants.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals
DEM - Artigos em revistas de circulação internacional com arbitragem científica

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