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https://hdl.handle.net/1822/51406
Título: | Orientational behaviors of silk fibroin hydrogels |
Autor(es): | Chen, Daqi Yin, Zhuping Wu, Feng Fu, Hua Kundu, Subhas C Lu, Shenzhou |
Palavras-chave: | Biomaterials Gels Mechanical Properties Structure–property relationships |
Data: | Mai-2017 |
Editora: | Wiley |
Revista: | Journal of Applied Polymer Science |
Citação: | Chen D., Yin Z., Wu F., Fu H., Kundu S. C., Lu S. Orientational behaviors of silk fibroin hydrogels, Journal Of Applied Polymer Science, Vol. 132, Issue 32, doi:10.1002/app.45050, 2017 |
Resumo(s): | In this study, a novel shear-induced silk fibroin hydrogel with three-dimensional (3D) anisotropic and oriented gel skeleton/network morphology is presented. Amphipathic anionic and nontoxic sodium surfactin is blended with the silk fibroin to decrease its gelation time during the mechanical shearing process. The fibroin/surfactin blended solutions undergo a facial shearing process to accomplish a solâ gel transition within one hour. The dynamic solâ gel transition kinetic analysis, gel skeleton/network morphology, and mechanical property measurements are determined in order to visualize the fibroin/surfactin solâ gel transition during the shearing process and its resulting hydrogel. The results demonstrate that there is significant b-sheet assembly from random coil conformations in the fibroin/surfactin blended system during the facile shearing process. The silk fibroin b-sheets further transform into a fibrous large-scale aggregation with orientational and parallel arrangements to the shearing direction. The shear-induced fibroin/ surfactin hydrogel exhibits notable anisotropic and oriented 3D skeleton/network morphology and a significant mechanical compressive strength in proportion to the shearing stress, compared with the control fibroin/surfactin hydrogel undergoing no shearing process. Due to its oriented gel skeleton/network structure and significantly enhanced mechanical properties, the shear-induced fibroin/ surfactin gel may be suitable as a biomaterial in 3D oriented tissue regeneration, including for nerves, the cultivation of bone cells, and the repair of defects in muscle and ligament tissues. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/51406 |
DOI: | 10.1002/app.45050 |
ISSN: | 0021-8995 |
e-ISSN: | 1097-4628 |
Versão da editora: | http://onlinelibrary.wiley.com/doi/10.1002/app.45050/abstract |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19329-Chen et al 2017 J. Applied Polymer Sci on line.pdf | 1,16 MB | Adobe PDF | Ver/Abrir |